慢性化脓性中耳炎患者真菌感染的临床分析

发布时间：2019-04-02 11:44

【摘要】：目的探讨慢性化脓性中耳炎患者真菌感染的相关因素及其临床诊治方法,为临床资料提供参考依据。方法随机选取2011-2013年收治的124例慢性化脓性中耳炎并发真菌感染的患者,行耳内分泌物的脓液培养,将感染者分为对照组和观察组,各62例,对照组采用水杨酸乙醇耳浴治疗,观察组采用聚维酮碘进行耳浴,分析真菌感染的类型,使用单因素及回归分析的方法归纳感染相关因素,及比较分析两组的临床疗效,采用SPSS17.0统计软件进行数据分析。结果真菌感染类型有丝状菌占79.0%、白色假丝酵母菌占27.5%、近平滑假丝酵母菌占27.5%、热带假丝酵母菌占4.8%、毛霉菌属占50.0%、平滑假丝酵母菌占6.4%及克柔假丝酵母菌占4.8%,logistic回归分析其相关因素为既往中耳炎史、常滴用抗菌药物史和污水入耳史,观察组治疗有效程度明显优于对照组,其总有效率为95.2%,而对照组的总有效率为69.4%,差异有统计学意义(P0.05)。结论慢性化脓性中耳炎合并真菌感染有丝状菌、白色假丝酵母菌、近平滑假丝酵母菌、热带假丝酵母菌、毛霉菌属、平滑假丝酵母菌及克柔假丝酵母菌等,其中以丝状菌及毛霉菌属居多,感染多与耳部病史或使用抗菌药有关,使用聚维酮碘治疗该疾病临床疗效满意,值得临床推广应用。
[Abstract]:Objective to investigate the clinical diagnosis and treatment of fungal infection in patients with chronic suppurative otitis media. Methods 124 patients with chronic suppurative otitis media complicated with fungal infection were randomly selected from 2011 to 2013. The infected persons were divided into two groups: control group (n = 62) and observation group (n = 62). The control group was treated with salicylic acid ethanol ear bath, the observation group was treated with povidone iodine ear bath, the type of fungal infection was analyzed, the factors related to infection were induced by single factor and regression analysis, and the clinical efficacy of the two groups was compared and analyzed. The data were analyzed by SPSS17.0 software. Results the types of fungal infection were filamentous bacteria (79.0%), Candida albicans (27.5%), near-smooth Candida (27.5%), Candida tropicalis (4.8%) and Mucor (50.0%). The proportion of Candida smooth was 6.4% and that of Candida clenorrhizae was 4.8%. Logistic regression analysis showed that the relative factors were the history of otitis media, the history of antibacterials and the history of sewage entering the ear. The therapeutic efficacy of the observation group was significantly better than that of the control group, and the therapeutic efficacy of the observation group was significantly better than that of the control group. The total effective rate was 95.2% in the control group and 69.4% in the control group, the difference was statistically significant (P0.05). Conclusion chronic suppurative otitis media complicated with fungal infection includes filamentous bacteria, Candida albicans, Candida tropicalis, Trichoderma, Candida smooth and Candida cluriformis, etc. Most of them are filamentous bacteria and Trichoderma. Most of the infections are related to the history of the ear or the use of antimicrobial agents. The clinical efficacy of povidone iodine in the treatment of this disease is satisfactory and worthy of clinical popularization and application.
【作者单位】：天津港口医院耳鼻喉科;天津港口医院药剂科;
【基金】：中华医院感染控制研究基金项目(ZHYY-2011-032)
【分类号】：R764.21

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