阿普唑仑渐进式加量治疗慢性耳鸣的疗效与安全性观察

发布时间：2019-05-06 19:41

【摘要】：目的:观察阿普唑仑渐进式加量治疗慢性耳鸣的临床疗效与安全性。方法:50例慢性耳鸣患者于第1、2周给予阿普唑仑片0.4 mg,口服,每晚睡前服用1次;第3、4周给予阿普唑仑片0.4 mg,口服,每日早晚各1次;第5、6周给予阿普唑仑片0.4 mg,口服,每日3次。耳鸣无效者,逐渐停药,停药以0.4 mg,每日2次,连用3 d;后改为0.4 mg,每日1次,连用3 d,后停药。有效者继续维持用药12周,随后逐渐停药,停药后随访3个月。观察所有患者的临床疗效,治疗前后耳鸣致残量表(THI)评分、视觉模拟量表(VAS)评分、耳鸣响度(TI)及不良反应发生情况。结果:总有效率为66.67%;所有患者治疗后THI评分、VAS评分、TI均显著低于治疗前,差异均有统计学意义(P0.05);治疗期间均未见明显不良反应发生。结论:阿普唑仑渐进式加量治疗慢性耳鸣疗效显著,且安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of alprazolam progressive dosage in the treatment of chronic tinnitus. Methods: fifty patients with chronic tinnitus were treated with alprazolam tablets 0.4 mg, at the 1st and 2nd week, once a night before bedtime, and 0.4 mg, at the 3rd and 4th week, once a day in the morning and in the evening, and the patients were treated with alprazolam tablets once a day for 3 weeks and 4 weeks. Alprazolam tablets were given 0.4 mg, orally 3 times a day for 5 and 6 weeks. If tinnitus was ineffective, the drug was stopped at 0.4 mg, twice a day for 3 days, then changed to 0.4 mg, once a day for 3 days, and then stopped for 3 days. The effective patients continued to take the drug for 12 weeks, then gradually stopped the drug, and the follow-up was 3 months after the drug was stopped. The clinical efficacy, tinnitus disability scale (THI), visual analogue scale (VAS), tinnitus loudness (TI) and adverse reactions were observed before and after treatment. Results: the total effective rate was 66.67%, the THI score, VAS score and TI of all patients were significantly lower than those before treatment (P0.05), and no obvious adverse reaction occurred during the treatment. Conclusion: alprazolam progressive dosage is effective and safe in the treatment of chronic tinnitus.
【作者单位】：深圳市第七人民医院;
【基金】：2011年盐田区第三批产业发展资料项目——阿普唑仑治疗耳鸣给药方案设计及疗效观察
【分类号】：R764.45

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