糖尿病对后发性白内障的影响及可能机制的初步研究

发布时间：2019-05-10 03:10

【摘要】：目的探讨2型糖尿病对后发性白内障的影响及其可能的分子机制。方法收集108例(108眼)白内障患者房水并行ELISA检测房水中IL-6含量,其中对照组(年龄相关性白内障患者)50例(50眼),试验组(2型糖尿病白内障患者)58例(58眼),比较两组最佳矫正视力、眼压、后发性白内障(posterior capsule opacification,PCO)发生率、PCO严重程度、房水中IL-6含量等。结果白内障超声乳化联合人工晶状体植入术均提高了两组患者术后最佳矫正视力,且对照组较试验组最佳矫正视力提高明显(P=0.002)。对照组术前、术后眼压分别为(13.93±3.25)mmHg(1 kPa=7.5 mmHg)、(14.60±4.35)mmHg,差异无统计学意义(P0.05);试验组术前、术后眼压分别为(14.18±3.56)mmHg、(15.12±4.66)mmHg,差异无统计学意义(P0.05)。对照组PCO发生率26.00%,试验组PCO发生率41.38%,两组间PCO发生率差异无统计学意义(P=0.095)。试验组房水中IL-6含量与后发性白内障呈正相关(r=0.731,P=0.001),且试验组房水中IL-6含量较对照组明显升高(P=0.012)。结论房水中IL-6含量可能促进了糖尿病患者PCO的发生发展,其具体机制尚需进一步研究。
[Abstract]:Objective to investigate the effect of type 2 diabetes mellitus (T2DM) on posterior cataract and its possible molecular mechanism. Methods the content of IL-6 in aqueous humor of 108 patients with cataract was measured by ELISA, including 50 cases (50 eyes) of age-related cataract and 58 cases (58 eyes) of type 2 diabetes mellitus cataract in the control group (50 eyes) and the experimental group (58 eyes). The best corrected visual acuity, intraocular pressure, the incidence of posterior cataract (posterior capsule opacification,PCO, the severity of PCO and the content of IL-6 in aqueous humor were compared between the two groups. Results the best corrected visual acuity of the two groups was improved by phacoemulsification combined with intraocular lens implantation, and the best corrected visual acuity of the control group was significantly higher than that of the experimental group (P 鈮，

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