大剂量甲基强的松龙冲击疗法治疗急性视神经炎有效性的系统评价

发布时间：2019-05-10 08:42

【摘要】：目的:系统评价大剂量甲基强的松龙冲击疗法与安慰剂治疗急性视神经炎的临床疗效和安全性。方法:检索Medline、OVID和中文科技期刊全文数据库、维普中文科技期刊数据库,检索时间截至2009年5月。按照文内所述纳入标准收集大剂量静脉应用激素冲击治疗急性视神经炎的相关研究文献,采用Meta分析对检索文献进行综合定量评价。结果:IVMP与安慰剂比较共纳入3个研究433例患者,IVMP在早期显示出相对优于安慰剂组的有效率,但在六个月后,两组有效率的差异无统计学意义。结论:早期静脉注射大剂量甲基强的松龙可加快急性视神经炎的康复,六个月后与安慰剂组无明显差别。在降低急性视神经炎的复发率、甲基强的松龙的最佳用药剂量及疗程仍需开展更多设计良好、方法学质量更高的随机对照试验来证实。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of high dose methylprednisolone pulse therapy and placebo in the treatment of acute optic neuropathy. Methods: Medline,OVID and Chinese sci-tech periodical full-text database and VIP Chinese sci-tech periodical database were searched up to May 2009. According to the inclusion criteria described in this paper, the related research literature of high dose intravenous hormone shock therapy for acute optic neuropathy was collected, and the retrieval literature was evaluated comprehensively and quantitatively by Meta analysis. Results: a total of 433 patients with IVMP and placebo were enrolled in the study. IVMP showed a relatively superior effective rate to the placebo group at an early stage, but after six months, there was no significant difference in the effective rate between the two groups. Conclusion: early intravenous injection of high dose methylprednisolone can accelerate the recovery of acute optic neuropathy, and there is no significant difference between the placebo group and the placebo group after six months. In order to reduce the recurrence rate of acute optic neuropathy, the best dose and course of treatment of methylprednisolone still need to be confirmed by more randomized controlled trials with good design and higher methodological quality.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R774.6

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