CDKN2A基因多态性与云南地区人群鼻咽癌的相关性研究

发布时间：2019-06-04 04:17

【摘要】：目的:研究云南地区人群CDKN2A基因rs1412829多态性与鼻咽癌的相关性。方法:随机抽取无血缘关系鼻咽癌患者95例和健康人100例,抽提基因组DNA,采用TaqMan探针基因分型法检测多态性。结果:(1)CDKN2A等位基因G在鼻咽癌组和对照组中的分布频率差异有显著性(P=0.023),G等位基因携带者患鼻咽癌的风险为A等位基因携带者的2.497倍(OR=2.497,95%CI=1.107~5.632,P=0.031);(2)鼻咽癌组与对照组AA、AG及GG的基因型频率分布有统计学差异(P=0.031);(3)鼻咽癌组含有G等位基因的个体病理分期较晚(Ⅳ期),差异有显著统计学意义(P0.001)。结论:CDKN2A基因rs1412829基因多态性中G等位基因可能是鼻咽癌的危险因素。该多态性与病理分期Ⅳ期间存在相关性,可以认为G等位基因突变较易出现在NPC病情发展的晚期。
[Abstract]:Objective: to study the relationship between rs1412829 polymorphism of CDKN2A gene and nasopharyngeal carcinoma (NPC) in Yunnan population. Methods: 95 unrelated nasopharyngeal carcinoma patients and 100 healthy people were randomly selected. Genomic DNA, was extracted and genotyped by TaqMan probe. Results: (1) there was significant difference in the distribution frequency of CDKN2A allele G between nasopharyngeal carcinoma group and control group (P 鈮，

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