咽喉反流与嗓音疾病的相关分析

发布时间：2019-07-13 16:56

【摘要】：目的探讨咽喉反流(laryngopharyngeal reflux,LPR)与嗓音疾病的相关关系。方法对103例疑有LPR相关症状的成年患者行反流症状指数量表(reflux symptom index,RSI)、反流体征计分量表(reflux finding score,RFS)、24小时双探头食管pH值监测,其中伴有嗓音疾病患者89例,分别为声带接触性肉芽肿组18例,慢性喉炎组19例,声带息肉组15例,声带白斑组21例,声带任克水肿组16例,余14例无嗓音疾病(对照组)。结果 103例患者中诊断为LPR的阳性率为46.6%(48/103),89例嗓音疾病患者LPR阳性率为48.30%(43/89),其中声带任克水肿组LPR阳性率(75%,12/16)、声带白斑组LPR阳性率(71.4%,15/21)显著高于对照组(35.7%,5/14)(P=0.030,P=0.036)。慢性喉炎组、声带任克水肿组RSI得分(13.5±7.2、13.9±2.3分)显著高于对照组(9.1±2.9分)(P=0.019,P=0.020);声带任克水肿组RFS得分(12.6±2.9分)显著高于对照组(7.6±2.9分)(P=0.009)。声带白斑组立位酸反流次数、卧位酸反流次数、总酸反流次数、立位酸反流时间、总酸反流时间显著高于对照组(P=0.011,P=0.004,P=0.015,P=0.034,P=0.027);声带任克水肿组立位酸反流次数、总酸反流次数、立位酸暴露百分比、总酸暴露百分比、立位酸反流时间、总酸反流时间显著高于对照组(P=0.025,P=0.039,P=0.041,P=0.030,P=0.012,P=0.011)。结论声带白斑、声带任克水肿与LPR相关性较高,两种疾病患者的咽喉部24小时食管pH值监测表现为反流次数多、时间长。
[Abstract]:Objective to investigate the relationship between throat reflux (laryngopharyngeal reflux,LPR) and voice diseases. Methods the reflux symptom index scale (reflux symptom index,RSI), reverse fluid symptom scale (reflux finding score,RFS) and 24-hour double probe esophageal pH monitoring were performed in 103 adult patients with suspected LPR-related symptoms, including 89 patients with voice diseases, 18 patients with vocal cord contact granuloma, 19 patients with chronic laryngitis, 15 patients with vocal cord polyps, 21 patients with vocal cord leukoplakia and 16 patients with vocal cord Ren Ke edema group, including 18 patients with vocal cord contact granuloma, 19 patients with chronic laryngitis, 15 patients with vocal cord polyp, 21 patients with vocal cord leukoplakia and 16 patients with vocal cord renker edema group. The remaining 14 cases had no voice disease (control group). Results the positive rate of LPR was 46.6% (48 / 103) in 103 patients and 48.30% (43 卤89) in 89 patients with voice disease. The positive rate of LPR in vocal cord edema group (75%, 12: 16) and vocal cord leukoplakia group (71.4%, 15 卤21) were significantly higher than those in control group (35.7%, 5 卤14) (P 鈮，

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