氟西汀治疗形觉剥夺性弱视猫的视觉电生理研究

发布时间：2019-08-07 08:42

【摘要】：目的研究新生猫制作形觉剥夺性弱视模型,采用图形视觉诱发电位检测氟西汀治疗前后的弱视猫,了解特征峰潜伏期和波幅的变化,进而观察氟西汀治疗形觉剥夺弱视猫的效果。方法采用德国Roland视觉电生理仪,对3例正常对照组猫和15例形觉剥夺性弱视猫建模12周,喂养氟西汀后4、8、12、16、20周进行图形视觉诱发电位的检测,对特征峰进行潜伏期和波幅的比较。结果正常对照组P波的潜伏期(48.33±3.51)ms,波幅(55.69±3.52)nV,单眼形觉剥夺猫P波的潜伏期(58.23±4.62)ms,波幅(38.24±2.96)nV,与正常对照组相比差异有统计学意义(P0.05)。氟西汀治疗4、8周时,P波的潜伏期较治疗前稍缩短,波幅稍增加,与氟西汀治疗前之间差异无统计学意义。治疗12、16、20周时,P波的潜伏期缩短,波幅增加,与氟西汀治疗前的形觉剥夺猫之间差异有统计学意义。结论氟西汀治疗形觉剥夺弱视猫能使其视觉电生理P波的潜伏期缩短,波幅增加,其变化过程类同于人类儿童弱视治愈过程中视觉电生理P波的潜伏期和波幅的变化趋势。
[Abstract]:Objective to study the model of form deprivation amblyopia made by newborn cats, to detect the amblyopia cats before and after fluoxetine treatment, to understand the changes of characteristic peak latency and amplitude, and to observe the effect of fluoxetine in the treatment of form deprivation amblyopia cats. Methods using German Roland visual electrophysiological instrument, 3 cats in normal control group and 15 cats with form deprivation amblyopia were modeled for 12 weeks. After feeding fluoxetine for 4, 8, 12, 16, 20 weeks, the pattern visual evoked potentials were measured, and the latent period and amplitude of characteristic peaks were compared. Results the latency of P wave in normal control group was (48.33 卤3.51) ms, amplitude (55.69 卤3.52) nV, and the latency of P wave in monocular form deprivation cat was (58.23 卤4.62) ms, amplitude (38.24 卤2.96) nV, which was significantly different from that in normal control group (P 0.05). After 4 weeks of fluoxetine treatment, the latency of P wave was slightly shorter and the amplitude of P wave was slightly higher than that before treatment, but there was no significant difference between fluoxetine and fluoxetine before treatment. At 12, 16, 20 weeks after treatment, the latency of P wave was shortened and the amplitude of P wave was increased, which was significantly different from that of form deprivation cats before fluoxetine treatment. Conclusion fluoxetine can shorten the latency and increase the amplitude of visual electrophysiological P wave in form deprived amblyopia cats. The change process of fluoxetine is similar to the change trend of visual electrophysiological P wave in the cure process of amblyopia in human children.
【作者单位】：南昌大学第二附属医院儿童眼科;
【基金】：江西省科技计划项目(编号:2010BSB00207)
【分类号】：R777.44

【参考文献】