serum pharmacochemistry of traditional Chinese medicine effi

  本文关键词：中药血清药物化学研究概况及其理论和方法拓展，由笔耕文化传播整理发布。

中药血清药物化学研究概况及其理论和方法拓展

Progress of serum pharmacochemistry of traditional Chinese medicine and further development of its theory and method

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YAN Guang-li, SUN Hui, ZHANG Ai-hua, HAN Ying, WANG Ping, WU Xiu-hong, MENG Xiang-cai, WANG Xi-jun （National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemis

黑龙江中医药大学国家中医药管理局中药血清药物化学重点研究室,黑龙江哈尔滨150040

文章摘要：中药血清药物化学是从中药/方剂口服给药后的血中移行成分中筛选药效物质基础的研究设计,其理念及方法符合中药整体作用模式,并体现了人体对药物的代谢、转化作用和药物在体内的相互作用,现已成为公认并被普遍应用的研究中药药效物质基础的有效方式。该文对以往中药血清药物化学的研究内容和研究方法进行梳理,在进一步认识中药复方给药形式的特殊性及方证对应疗效的专属性基础上,提出整合系统生物学的中药血清药物化学新研究策略：以证候为切入点,以方剂为研究对象,在利用系统生物学方法阐明证候生物标记物的前提下,评价方剂整体效应,在有效的状态下,筛选与效应生物标记物高度关联的中药血清移行成分,发现并确定中药的药效物质基础。通过整合系统生物学方法,中药血清药物化学的理论与方法进一步扩展,将开启诠释中医药理论的新篇章。

Abstr：Serum pharmacochemistry of traditional Chinese medicine（ TCM） is designed to screen the efficacy material base of TCMs from the constituents absorbed into the blood after oral administration. The theory and method is in accordance with the effect characteristics of TCMs,and reflects the interaction between the body and the drugs,has become an effective pathway for researching the efficacy material base of TCMs which has been recognized and used widely. In the paper,the previous research contents and methods of the serum pharmacochemistry of TCM were reviewed,and on the basis of the further validity of the special administration form of the TCM formula and the corresponding property to TCM syndrome,the new strategy of serum pharmacochemistry of TCM integrating the metabonomics technologies was put forward. According to the strategy,we take the biological characters of TCM syndrome as a research starting point,taking TCM formula as object,using the metabolic biomarkers of syndromes or disease to evaluate the therapeutic effect of formula and screen the compounds of TCMs in serum which are highly correlated with the metabolic biomarkers through the correlation analysis,and by further biological validation to finally confirm the efficacy material basis of TCMs. Integrating with the systems biology technologies,the theory and method of serum pharmacochemistry of TCM will further develop,and open a new chapter in the interpretation of the theory of TCM.

文章关键词：

Keyword：:serum pharmacochemistry of traditional Chinese medicine efficacy material base formula systems biology future development

课题项目：国家自然科学基金重点项目（81430093）;国家自然科学基金面上项目（81173500,81373930,81473584）;国家自然科学基金青年基金项目（81202639,81302905）

  本文关键词：中药血清药物化学研究概况及其理论和方法拓展，由笔耕文化传播整理发布。