基于网络药理学的罗格列酮复方作用机制探讨

发布时间：2018-01-13 10:21

本文关键词：基于网络药理学的罗格列酮复方作用机制探讨　出处：《药学学报》2015年03期 　论文类型：期刊论文

【摘要】：在新药研发及药理学研究领域,网络药理学的应用日渐广泛,方法层出不穷。本研究以罗格列酮复方为研究对象,采用3种网络药理学预测方法进行靶点预测和作用机制探讨,并比较评价3种预测方法的异同。研究发现,3种方法预测得到的结果并不相同,但钙信号转导通路在3种方法中均可预测到。经生物信息学分析发现,这条通路与糖尿病及糖尿病引起的认知障碍相关,表明钙信号转导通路是罗格列酮复方作用过程中重要的信号调节通路。本研究为该复方作用机制的进一步阐释提供了线索,同时也为实际研究中网络药理学靶点预测方法的选择和应用提供参考。
[Abstract]:In the field of new drug research and pharmacology research, the application of network pharmacology is more and more extensive, and the methods are emerging in endlessly. This study takes rosiglitazone compound as the research object. The target prediction and the mechanism of action were discussed by using three network pharmacological prediction methods, and the similarities and differences of the three prediction methods were compared and evaluated. The results of the three methods were not the same. But calcium signal transduction pathway can be predicted in three methods. Bioinformatics analysis shows that this pathway is related to diabetes mellitus and the cognitive impairment caused by diabetes mellitus. The results suggest that calcium signaling pathway is an important signal regulation pathway in the course of rosiglitazone compound action. This study provides clues for further explanation of the action mechanism of rosiglitazone compound. It also provides a reference for the selection and application of network pharmacological target prediction methods.
【作者单位】：江西中医药大学药学院;清华大学化学系生命有机磷化学及化学生物学教育部重点实验室;辽宁中医药大学药学院;
【基金】：国家自然科学基金资助项目(81302731)
【分类号】：R96
【正文快照】： 网络药理学是一门对生物系统的网络进行分析并选取特定信号节点进行多靶点药物分子设计的新学科。通过生物学网络中节点的连接和关系来分析网络特性,进而阐明药物的作用机制,为分析药物的作用提供了崭新的角度[1,2]。网络药理学的发展推动了对药物作用机制的重新认识,为药物发

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