维生素E侧链—异植物醇合成工艺研究

发布时间：2018-01-13 16:24

本文关键词：维生素E侧链—异植物醇合成工艺研究　出处：《重庆医科大学》2014年硕士论文　论文类型：学位论文

更多相关文章： 异植物醇 合成 格氏反应 Carroll重排

【摘要】：目的：改进异植物醇合成工艺。方法：以丙酮为起始原料，与氯乙烯经过格氏反应得到2-甲基-3-丁烯-2-醇，再与乙酰乙酸甲酯经过Carroll重排得到甲基庚烯酮，再经过两次相同的格氏反应和Carroll重排得到法尼基丙酮，然后还原得到六氢法尼基丙酮，，最后再经格氏反应得到异植物醇。结果：目标产物和关键中间体经MS谱，1H-NMR谱等确证了结构。结论：改进后的工艺路线生产设备简单，条件温和，收率高（总收率64.4%），适合大规模化生产。
[Abstract]:Objective: to improve the synthesis process of isophylls. Methods: 2-methyl-3-butene-2-ol was obtained by Grignard reaction of acetone with vinyl chloride and then rearranged with methyl acetoacetate through Carroll to obtain methylheptene ketone. After the same Grignard reaction and Carroll rearrangement, the phanninyl acetone was obtained, then reduced to hexahydrofarinoacetone, and finally isophyllol was obtained by Grignard reaction. Results: the structures of the target products and the key intermediates were confirmed by MS 1H-NMR spectra. Conclusion: the improved process has the advantages of simple production equipment, mild conditions and high yield (total yield 64.4%), which is suitable for large-scale production.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R914

【共引文献】