膦甲酸钠对硫酸头孢噻利大鼠体内药动学的影响

发布时间：2018-01-15 16:00

  本文关键词：膦甲酸钠对硫酸头孢噻利大鼠体内药动学的影响　出处：《中国医药工业杂志》2015年05期 　论文类型：期刊论文

  更多相关文章： 硫酸头孢噻利 膦甲酸钠 高效液相色谱 药动学

【摘要】：考察了膦甲酸钠对硫酸头孢噻利在大鼠体内药动学的影响。健康Wistar大鼠随机分为试验组与对照组,每组20只。试验组大鼠尾静脉注射膦甲酸钠360 mg/kg,随后即刻注射硫酸头孢噻利200 mg/kg;对照组仅注射硫酸头孢噻利200 mg/kg。采用HPLC法测定血浆中硫酸头孢噻利浓度,并拟合药动学参数,试验组和对照组结果如下:t1/2(1.76±0.57)和(1.22±0.51)h,cmax(1 314.37±196.70)和(1 470.18±321.38)μg/ml,AUC0→24 h(863.19±189.46)和(799.57±203.39)μg·h·ml-1,AUC0→∞(898.81±214.25)和(800.02±207.04)μg·h·ml-1,V(0.56±0.18)和(0.45±0.17)L/kg,CL(0.23±0.05)和(0.27±0.07)L·h-1·kg-1。合用膦甲酸钠后,硫酸头孢噻利在大鼠体内的t1/2和V显著升高,表明膦甲酸钠与硫酸头孢噻利可能竞争同一排泄途径,减缓硫酸头孢噻利的排泄。
[Abstract]:The effect of phosphonium formate on the pharmacokinetics of ceftithione sulfate in rats was investigated. Healthy Wistar rats were randomly divided into two groups: the experimental group and the control group. 20 rats in each group were injected with sodium phosphonate 360 mg / kg via caudal vein and then 200 mg / kg ceftiazil sulfate was injected immediately afterwards. The control group was only injected with ceftiazol sulfate 200mg / kg. The plasma ceftithiazole sulfate concentration was determined by HPLC method and the pharmacokinetic parameters were fitted. The results of the test group and the control group were as follows: 1: t / 1 / 2 (1.76 卤0.57) and 1.22 卤0.51h. Cmax(1 314.37 卤196.70) and 1,470.18 卤321.38 渭 g / ml AUC0. 鈫，

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