动脉血栓相关治疗靶点及新药研究进展

发布时间：2018-01-15 16:16

本文关键词：动脉血栓相关治疗靶点及新药研究进展　出处：《中国药科大学学报》2017年03期 　论文类型：期刊论文

【摘要】：动脉血栓(arterial thrombosis,AT)为一种临床常见病及多发病,并可诱发急性心肌梗死、缺血性脑卒中等缺血性心脑血管疾病,具有高致残率和高致死率的特点,严重危害人类健康。AT形成过程中涉及到内皮细胞、白细胞、血小板等多种因素的参与。积极寻找AT形成过程中可干预进程的治疗靶点,并根据靶点开发相关治疗药物具有重大的意义。本文就近5年来防治AT形成和抗栓治疗涉及到的相关靶点研究现状,及针对上述靶点研发的抗栓药物进展研究作一综述,以期为研制治疗AT的创新药物提供可能线索和依据。
[Abstract]:Arterial thrombosis (arterial thrombosis AT) is a common disease and frequently occurring disease, which can cause acute myocardial infarction, ischemic stroke and ischemic cerebrovascular disease, with high mutilation rate and high death rate, related to endothelial cells, the formation process of serious harm to human health.AT in white blood cells, a variety of factors platelet participation. Actively looking for therapeutic targets in the formation process of AT intervention process, and according to the target of development is of great significance for drug related targets. The research status in recent 5 years, the prevention and control of AT formation and antithrombotic therapy involved, and according to the above research target to develop anti thrombus drugs were summarized, in order to provide possible clues and basis for the development of innovative drugs for the treatment of AT.

【作者单位】：中国药科大学江苏省中药评价与转化重点实验室;中国药科大学中药复方研究室;
【基金】：国家自然科学基金资助项目(No.81274131)~~
【分类号】：R972
【正文快照】： 引用本文李龙,寇俊萍.动脉血栓相关治疗靶点及新药研究进展[J].中国药科大学学报,2017,48(3):251-258.Cite this article as:LI Long,KOU Junping.Advances in the research of therapeutic targets and the development of new drugs against arterial throm-bosis[J].J Chin

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