吸入器格栅对甘露醇粉末分散效果的影响

发布时间：2018-01-21 16:34

本文关键词： 格栅粉雾剂吸入器雾化多级液体撞击器计算流体力学　出处：《中国医药工业杂志》2016年11期 　论文类型：期刊论文

【摘要】：基于Osmohaler~(TM)装置,研究了3种具有不同格栅结构和格栅安装位置的粉雾剂吸入器的雾化性能。在60 L/min气流流量下,使用多级液体撞击器(multistage liquid impinger,MSLI)评价了模型药物甘露醇粉末的分散效果;使用计算流体力学(computational fluid dynamics,CFD)模型分析了装置中流场和颗粒的运动状态。结果表明,3种装置具有基本相同的分散机制,但雾化性能有差异。对原装置内部格栅结构及材质的修改,造成了颗粒在装置中的残留增多、微细粒子剂量(Fine Particle Dose,FPD)降低;在出口处设置的格栅并没有明显提高颗粒的分散及沉积效果。同时,通过体外沉积试验和数值模拟研究还观察到,MSLI前三级的沉积量变化趋势与相对应的微细颗粒在装置出口处运动速度的变化规律具有一定的相关性。
[Abstract]:The atomization properties of three kinds of powder aerosol inhalers with different grille structures and grid installation positions were studied based on the Osmohalerian TMU device. At 60 L / min flow rate, the atomization performance of three kinds of aerosol inhalers was studied. The dispersion effect of the model drug mannitol powder was evaluated by multistage liquid impeller MSLI. The flow field and the motion state of particles in the device are analyzed by using the computational fluid dynamic CFDs model. The three devices have the same dispersing mechanism, but the atomization performance is different. The modification of the inner grille structure and material of the original device results in the increase of the particle residue in the device. The dose of fine Particle was decreased. The grid at the exit did not significantly improve the dispersion and deposition of particles. At the same time, through in vitro deposition test and numerical simulation study also observed. The variation trend of deposition amount in the first three stages of MSLI is related to the movement velocity of the corresponding fine particles at the outlet of the device.
【作者单位】：上海理工大学医疗器械与食品学院;Faculty
【分类号】：R94
【正文快照】： 型3种类型[1],各自的典型代表分别为Aerolizer?、Diskus?、Turbuhaler?。药物粉末分散过程较为复杂,颗粒间的团聚、颗粒与流体的相互作用、颗粒与装置壁面的碰撞以及颗粒间静电作用等均会影响药物粉末的分散、沉积效果[2—3]。除制剂外,吸入器的设计被认为是影响粉雾剂分散、

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