壬苯醇醚聚ε-己内酯电纺纤维膜的表征及释放

发布时间：2018-01-22 08:11

本文关键词： 壬苯醇醚纤维静电纺丝聚ε-己内酯缓释　出处：《沈阳药科大学学报》2015年04期 　论文类型：期刊论文

【摘要】：目的以聚ε-己内酯为成纤维材料制备载有壬苯醇醚的膜,开发具有一定缓释特征的外用避孕药膜。方法将壬苯醇醚与聚ε-己内酯共同溶解于二氯甲烷中得均相溶液后静电纺丝,对所得纤维膜采用扫描电子显微镜,广角X-射线衍射,差示热分析进行表征,分析壬苯醇醚与聚ε-己内酯的结合状态,I2-IK显色法测定从纤维释放至介质中的壬苯醇醚量,绘制释放曲线并对其进行拟合。结果所得纤维均为微米级,添加壬苯醇醚后,纤维直径明显增加,壬苯醇醚与聚ε-己内酯有着较好的结合,壬苯醇醚突释明显,15 min至2 h期间呈现缓释,2 h后纤维释放壬苯醇醚达平台期,随着包载量的增高,突释量和平台期放量也随之增高,且成线性。释放曲线线性拟合后时间与释放百分量的关系符合2种方程。结论以聚ε-己内酯为载体材料包裹壬苯醇醚可以电纺得到微米级纤维所形成的膜,其释放行为满足作为新型理想外用杀精子药剂进行使用的条件。
[Abstract]:Objective to prepare the membrane containing nonyl phenyl alcohol ether with poly蔚 -caprolactone as fiber material. Methods Non-phenylether and poly蔚 -caprolactone were dissolved in homogeneous solution of dichloromethane and then electrospun. The fiber membrane was prepared by scanning electron microscope. Wide angle X-ray diffraction and differential thermal analysis were used to analyze the binding state of nonylphenyl alcohol ether and poly蔚 -caprolactone. The content of nonyl alcohol ether released from fiber to medium was determined by I2-IK colorimetric method. The release curve was drawn and fitted. Results all the fibers were of micron order. The diameter of the fibers increased obviously after the addition of nonyl phenyl alcohol ether, and the combination of nonphenyl alcohol ether and poly (蔚 -caprolactone) was better. The sudden release of nonylphenyl alcohol ethers was observed during 15 min to 2 h after sustained release for 2 h, and then the fiber released nonphenyl alcohol ethers reached the plateau stage. With the increase of the encapsulation amount, the sudden release amount and the plateau release amount also increased. The relationship between the time after linear fitting of release curve and the release 100 component accords with two kinds of equations. Conclusion the film formed by micron fiber can be electrospun with poly蔚 -caprolactone as carrier material. Its release behavior satisfied the condition of using as a new ideal spermicidal agent for external use.
【作者单位】：天津工业大学中空纤维膜材料与膜过程国家重点实验室;辽宁医学院药学院;
【基金】：国家自然科学基金资助项目(51102178)
【分类号】：R94
【正文快照】： 非离子型表面活性剂壬苯醇醚(nonoxinol,NNX,结构式见图1)为一种外用的杀精子剂,上市的制剂一般为水性基质载药系统如水凝胶或者由亲水的高分子材料为基材形成的膜剂,但是在储存和使用时会有稳定性和使用不便等问题的出现[1-2]。开发其新的给药剂型很有意义。近10年来,人们采

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