阿莫西林在猪体内的药动学研究

发布时间：2018-01-22 14:42

本文关键词： 阿莫西林高效液相色谱药物动力学猪　出处：《畜牧与兽医》2015年02期 　论文类型：期刊论文

【摘要】：选取18头平均体重(15±5)kg、健康的杜长大三元杂交去势公猪,肌肉注射15 mg/kg阿莫西林三水合物水溶液,给药后分别于0.17、0.33、0.5、0.67、1、1.5、2、4、6、8、10、12和24 h采集前腔静脉血液,高效液相色谱法检测血浆中阿莫西林的含量。阿莫西林的血药浓度-时间数据采用Win Nonlin(Version 5.2.1)软件进行拟合,计算药动学参数。结果显示:末端消除速率常数λz=(0.40±0.04)h-1,消除半衰期T1/2λz=(1.74±0.16)h,峰时Tmax=(1.53±0.40)h,峰浓度Cmax=(5.62±0.74)μg·m L-1,药时曲线下面积AUCall=(25.35±2.25)h·μg·m L-1,表观分布容积Vz=(1.64±0.38)L·kg-1,消除速率常数CLz=(0.65±0.12)L·h-1·kg-1,平均滞留时间MRT=(3.20±0.41)h。结果表明:阿莫西林三水合物在健康猪体内的主要药动学特征为肌注给药吸收迅速、达峰时间短、消除迅速。
[Abstract]:Eighteen ovariectomized boars with average body weight of 15 卤5 kg were injected intramuscularly with amoxicillin trihydrate solution for 15 mg/kg. The blood samples of anterior vena cava were collected at 0.33 ~ (0.3) ~ 0.67 ~ 0.67 ~ (-1) ~ 1.5A ~ (2) ~ (6) ~ (6) ~ (8) ~ 10 ~ (12) and 24 h ~ (th). High performance liquid chromatography (HPLC) was used to determine the content of amoxicillin in plasma. The plasma concentration-time data of amoxicillin were fitted with Win Nonlin(Version 5.2.1) software. The pharmacokinetic parameters were calculated. The results showed that the rate constant 位 _ znn _ (0.40 卤0.04) h ~ (-1) and the elimination half-life T _ (1 / 2) 位 _ (zN) _ (1.74 卤0.16) h were obtained. The peak concentration was 0.74 渭 g 路mL ~ (-1) and Tmax=(1.53 卤0.40 渭 g 路mL ~ (-1) 路mL ~ (-1). The area under the drug time curve was AUCall=(25.35 卤2.25 h 路渭 g 路ml -1, and the apparent distribution volume was Vz=(1.64 卤0.38 L 路kg-1. The rate constant CLz=(0.65 卤0.12 L 路h -1 路kg-1 was eliminated. The results showed that the main pharmacokinetic characteristics of amoxicillin trihydrate in healthy pigs were rapid absorption by intramuscular injection and short peak time. Eliminate quickly.
【作者单位】：长江大学动物科学学院;
【分类号】：R965
【正文快照】： 阿莫西林又名羟氨苄青霉素,是一种广谱青霉素类抗生素,对包括胸膜肺炎放线杆菌在内的猪呼吸系统的主要病原菌有很强的活性[1]。阿莫西林给药后在肺组织可以达到较高的浓度,它对猪胸膜肺炎放线杆菌的最小抑菌浓度为0.1μg/m L[1-3]。研究表明阿莫西林在猪气管和支气管中的浓度

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