随机森林法用于分析阿糖胞苷致不良反应发生的影响因素

发布时间：2018-01-28 05:51

本文关键词： 随机森林法阿糖胞苷药品不良反应影响因素　出处：《中国药房》2015年08期 　论文类型：期刊论文

【摘要】：目的:采用随机森林法分析阿糖胞苷致不良反应(ADR)发生的影响因素。方法:对2013年5月-2014年5月辽宁省ADR监测系统收集到的阿糖胞苷致ADR病例报告100例,选取其影响因素,包括体质量、性别、年龄、给药途径、药品剂型、用药剂量、ADR发生季节、触发时间、生产厂家等,并将其作为解释变量。采用随机森林法对阿糖胞苷致ADR的影响因素进行分析,并将其与患者实际情况进行对比,以考察随机森林法在该过程中实施的可行性。结果:分别对患者ADR症状进行观察,其中患者通过静脉注射及鞘内用药发生的ADR较皮下注射多,差异有统计学意义(P0.05);触发时间对ADR症状有明显影响(P0.05)。结论:随机森林法能够准确地从复杂的数据中对真实的影响因素进行识别,临床意义重大。
[Abstract]:Objective: to analyze the adverse reactions induced by cytarabine by random forest method. Methods: from May 2013 to May 2014, 100 cases of cytarabine induced ADR were collected from Liaoning Province ADR surveillance system. The influencing factors were selected, including body mass, sex, age, route of administration, dosage form, occurrence season of ADR, trigger time, manufacturer and so on. The influencing factors of cytosine arabinoside induced ADR were analyzed by random forest method and compared with the actual situation of patients. Results: the symptoms of ADR in patients were observed, and the incidence of ADR by intravenous injection and intrathecal administration was more than that by subcutaneous injection. The difference was statistically significant (P 0.05). The trigger time has a significant effect on the symptoms of ADR P0.05.Conclusion: the random forest method can accurately identify the real influencing factors from the complex data, which is of great clinical significance.
【作者单位】：解放军第149医院;
【分类号】：R979.1
【正文快照】： 近几年来,阿糖胞苷不良反应(ADR)的发生率明显升高,行比较、分析,得出阿糖胞苷致ADR发生的影响因素,评价随严重影响广大患者的临床治疗效果。目前在我国,随着医药机森林法用于分析阿糖胞苷致ADR发生影响因素的可行性。技术水平的不断发展,越来越多的综合统计方法被应用于对其

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