新型纳米棒药物载体的合成及性能研究进展

发布时间：2018-02-07 13:38

本文关键词： 纳米棒载体复合材料纳米材料分布细胞毒性　出处：《化工进展》2017年09期 　论文类型：期刊论文

【摘要】：纳米棒拥有独特的结构、优良的性能和重要的生物医学应用价值,已逐步成为一类新型药物载体。本文介绍了近年来纳米棒作为药物载体的相关研究,分别对金纳米棒、羟磷灰石纳米棒、介孔硅纳米棒等典型药物载体的制备和应用进行了详细阐述,重点分析了金纳米棒、Au@SiO_2复合纳米棒、Au@C复合纳米棒以及中空金纳米棒等药物载体的一般合成工艺,简述了这些基于金纳米棒载体的表面修饰、功能化、负载及控释技术。随后对常见的纳米棒载体的药物控释性能进行了比较和评价,提出了3种常见的纳米棒载体缓释方式:一是载体直接分散缓释法,该法经济易行,但所需载体用量较大且易损失;二是透析袋式缓释法,该法所需载体用量较小、无需分离,但需购置半透膜;三是比色皿式缓释法,该法主要针对于光敏性载体。详细讨论了纳米棒载体的尺寸和体外细胞毒性,并对纳米棒载体的体内分布、免疫清除等体内代谢性能进行了介绍,最后对纳米棒载体的发展进行了展望,认为基于纳米棒的多刺激响应型异质载体、中空纳米棒载体和纳米管类载体可能是今后的研究热点。
[Abstract]:Nanorods, with their unique structure, excellent performance and important biomedical application value, have gradually become a kind of new drug carrier. The preparation and application of typical drug carriers such as hydroxyapatite nanorods and mesoporous silicon nanorods were described in detail. The surface modification, functionalization, loading and controlled release techniques based on gold nanorods were briefly described. Then, the drug controlled release properties of common nanorods were compared and evaluated. Three common methods of sustained release of nanorod carrier were put forward: one was the method of direct dispersion of carrier, which was economical, but the amount of carrier needed was large and easy to lose, the other was the method of dialysis bag sustained release, which needed less carrier and needed no separation. But it is necessary to purchase semi-permeable membrane, and the third is colorimetric slow-release method, which is mainly aimed at photosensitive carrier. The size of nanorod carrier and its cytotoxicity in vitro are discussed in detail, and the distribution of nanorod carrier in vivo is discussed in detail. Finally, the development of nanorod carriers is prospected, and it is considered that multi-stimuli responsive heterogeneous carriers based on nanorods are based on nanorods. Hollow nanorods and nanotube carriers may be the focus of research in the future.
【作者单位】：皖南医学院药学院;江苏大学化学与化工学院;
【基金】：安徽省高校自然科学基金重点项目(KJ2015A158) 安徽省高校优秀青年人才支持计划重点项目(gxyq ZD2016169) 中国博士后科学基金面上项目(2015M581731) 江苏省博士后科研资助计划项目(1501066C) 大学生创新创业计划项目(201610368119,201510368040,201510368121)
【分类号】：R943;TB383.1

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