荷载紫杉醇介孔二氧化硅纳米粒的制备及体外性能

发布时间：2018-02-10 20:36

本文关键词： 介孔二氧化硅纳米粒紫杉醇体外释放抗肿瘤活性　出处：《中国药科大学学报》2015年06期 　论文类型：期刊论文

【摘要】：介孔二氧化硅纳米粒(mesoporous silica nanoparticle,MSN)作为药物载体已成为纳米给药系统研究的热点。以无序孔道的MSN为载体,以溶剂吸附法负载化疗药物紫杉醇(PTX),从而制备得到PTX@MSN。考察了PTX@MSN的理化性质、药物体外释放行为和体外抗肿瘤活性等特性。研究结果表明,PTX@MSN载药量为(23.76±1.14)%,在水性介质中分散良好,粒径约为250 nm,电位为-(8.01±1.81)mV。PTX@MSN具有药物缓释特性,24h后PTX累积释放率为(23.62±2.15)%。细胞毒性结果显示,空白MSN生物安全性良好,而PTX@MSN组对人肝癌HepG2细胞的杀伤作用较市售Taxol组强。本研究为MSN递送抗肿瘤药物提供一定的理论与应用基础。
[Abstract]:Mesoporous silica nanoparticles (mesoporous silica nanoparticlein MSN) as drug carriers have become a hot topic in the study of drug delivery systems. The chemotherapeutic drug paclitaxel (PTX) was prepared by solvent adsorption with disordered MSN as the carrier, and the physicochemical properties of PTX@MSN were investigated. The drug release behavior in vitro and anti-tumor activity in vitro were studied. The results showed that the drug load of PTX @ MSN was 23.76 卤1.14%, and the drug was dispersed well in aqueous medium. The cumulative release rate of PTX was 23.62 卤2.15% after 24 hours of sustained release. The cytotoxic results showed that the biological safety of blank MSN was good, and the potential was -8.01 卤1.81mV.PTX @ MSN had the characteristics of sustained release of the drug for 24 hours, and the cumulative release rate of PTX was 23.62 卤2.15g / min. The cytotoxic results showed that the biological safety of MSN was good. The killing effect of PTX@MSN group on human hepatoma HepG2 cells was stronger than that of commercial Taxol group. This study provides a theoretical and practical basis for the delivery of antitumor drugs by MSN.
【作者单位】：中国药科大学新药研究中心江苏省代谢性疾病药物研究重点实验室;
【分类号】：R943

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