离子型温敏纳米凝胶的制备及其载药性能评价

发布时间：2018-02-10 22:35

  本文关键词： 纳米凝胶 无皂乳液聚合 药物载体 温敏性 静电吸附　出处：《中国医院药学杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的:制备离子型N-异丙基丙烯酰胺(NIPAM)类温敏纳米凝胶用于静电吸附载药。方法:分别采用乳液聚合(EP)、种子乳液聚合(SEP)和无皂乳液聚合(SFEP)法将NIPAM与丙烯酸(AA)或甲基丙烯酸β-硫酸乙基酯(SEMA)共聚制成纳米凝胶,通过TEM、PCS、电位滴定等方法表征各凝胶颗粒的形貌尺寸、温敏行为及单体含量。以阿霉素为模型药物,考察纳米凝胶通过静电吸附载药的能力。结果:EP或SEP法制备的AA凝胶(PNA)单分散性和温敏性良好,单体能完全参与聚合,当温度从20℃升至45℃时,粒径约从100 nm降至50 nm。EP法制备的SEMA凝胶(PNS)单分散性较差,改用SFEP法能提高凝胶的单分散性,但是约40%单体没有参与共聚。PNS凝胶的温敏性仍得到保留,20~45℃下粒径约为200~140 nm。核-壳型纳米凝胶的载药量和包封率最低,随着交联密度的增大,PNA纳米凝胶的载药量也相应提高。PNS纳米凝胶的载药量和包封率分别为14.6%和85.3%,载药能力最强,约为PNA纳米凝胶的2~3倍。PNS纳米凝胶负载的药物在纯水中24 h不释放,在生理盐水中约2 h释放完全。结论:PNS纳米凝胶粒径均一,具有温敏性,载药性能好,有望成为一个智能响应性纳米药物载体。
[Abstract]:Objective: to prepare ionic N- isopropyl acrylamide (NIPAM)-type thermo-sensitive nanogels for electrostatic adsorption of drugs. Methods: NIPAM and acrylic acid were prepared by emulsion polymerization (EPN), seed emulsion polymerization (SEP) and soap-free emulsion polymerization (Sep) respectively. Nano-gel was prepared by copolymerization of 尾 -ethyl acrylate and SEMA. The morphology, temperature-sensitive behavior and monomer content of each gel particle were characterized by TEMP-PCS and potentiometric titration. Adriamycin was used as the model drug. Results the monodispersity and temperature sensitivity of AA gel prepared by SEP or% EP method were good, and the monomer could participate in the polymerization completely. When the temperature rose from 20 鈩，

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