环丙沙星致不良反应213例文献分析

发布时间：2018-02-16 20:57

本文关键词： 环丙沙星不良反应文献分析　出处：《中国药房》2017年06期 　论文类型：期刊论文

【摘要】：目的:了解环丙沙星不良反应(ADR)发生的特点和一般规律,为临床合理用药提供参考。方法:以"环丙沙星""不良反应"为主题词,检索万方数据库1998-2015年收载的期刊文献,对患者性别、年龄、给药途径、原患疾病、ADR发生时间、ADR累及器官/系统及主要临床表现、过敏史、预后与转归进行统计分析。结果:共检索得到有效文献181篇,共计213例患者。其中,男性多于女性(57.28%vs.42.72%);多在用药首日发生(130例,61.03%);静脉滴注(179例,84.04%)为主要给药方式;ADR主要累及器官/系统为全身性损害(71例,33.33%)及神经系统损害(50例,23.47%);临床表现以过敏性休克(65例,30.52%)为主,严重者可致死亡(3例,1.41%)。结论:临床应严格掌握环丙沙星的适应证,合理用药,对用药过程严密观察,警惕ADR的发生。
[Abstract]:Objective: to understand the characteristics and general rules of ciprofloxacin adverse reactions (ADRs), and to provide reference for rational drug use in clinic. Methods: using "ciprofloxacin" and "adverse reactions" as the theme words, we searched the literature of journals collected in Wanfang database from 1998 to 2015. Sex, age, route of administration, time of occurrence of ADR and main clinical manifestations, allergic history, prognosis and outcome of ADR were statistically analyzed. Results: 181 effective literatures were obtained. A total of 213 patients. More males than females 57.28vs.42.72m; 130 cases with 61.03s on the first day of medication; 179 cases with intravenous drip (84.04). ADR mainly involved the organs / system in 71 cases with systemic damage (33.33 33) and nervous system damage in 50 cases (23.474747474.The main clinical manifestations were hypersensitive shock in 65 cases (35. 522%)), and the clinical manifestations were mainly anaphylactic shock in 65 cases (35. 522%) and anaphylactic shock in 65 cases (35. 52%). Conclusion: the indication of ciprofloxacin should be strictly grasped, the rational use of ciprofloxacin should be strictly grasped, the course of medication should be observed closely and the occurrence of ADR should be warned.
【作者单位】：上海闵行区中心医院药剂科;
【分类号】：R978.1

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