55例丙戊酸钠血药浓度监测结果分析

发布时间：2018-02-20 15:39

本文关键词： 丙戊酸血药浓度癫痫　出处：《世界最新医学信息文摘》2016年72期 　论文类型：期刊论文

【摘要】：目的分析癫痫患者性别、体重、年龄以及药物剂型对丙戊酸血药浓度的影响,以期为临床合理用药提供一定的理论依据。方法收集患者基本信息,采用全自动免疫系统监测血药浓度,利用统计学方法分析55例癫痫患者的性别、体重、年龄、剂型对丙戊酸血药浓度的影响,并对结果进行分析。结果 25例患者(45.45%)丙戊酸钠血药浓度在有效治疗范围(50-100μg/m L)内,26例(47.28%)低于50μg/m L,4例(7.27%)高于100μg/m L;不同性别患者间的丙戊酸钠血药浓度虽无明显差异(P0.05),但却与年龄、体重以及药物剂型存在相关性。结论丙戊酸钠血药浓度个体差异大,且受癫痫患者年龄、体重以及药物剂型等因素的影响。因此,在服药期间应及时监测丙戊酸血药浓度,结合患者自身因素,及时调整用药剂量,以提高临床疗效、降低不良反应。
[Abstract]:Objective to analyze the effect of sex, body weight, age and dosage form on valproic acid concentration in patients with epilepsy, in order to provide some theoretical basis for clinical rational use of valproic acid. The influence of sex, body weight, age and dosage form of 55 epileptic patients on valproic acid concentration was analyzed by automatic immune system. Results the blood concentration of valproate in 25 patients (45.45) was lower than 50 渭 g / mL in 26 patients (47.28 渭 g / mL) and was lower than 50 渭 g / mL in 4 cases (7.27%). The blood concentration of sodium valproate was higher than 100 渭 g / mL in patients of different genders. Although there was no significant difference in plasma concentration of valproate between different genders, the concentration of valproate was significantly higher than that of age. Conclusion the blood concentration of valproate is different in individuals and affected by the age, body weight and dosage form of epileptic patients. Therefore, the concentration of valproic acid in blood should be monitored in time. In order to improve the clinical efficacy and reduce adverse reactions, the dosage should be adjusted in time according to the patient's own factors.
【作者单位】：大理大学药学与化学学院;昆明市第一人民医院药学部;
【分类号】：R969

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