喷雾干燥工艺制备枸橼酸喷托维林微粉

发布时间：2018-02-26 08:06

  本文关键词： 喷雾干燥 枸橼酸喷托维林 粒度分布 微观结构 微观形貌　出处：《中国粉体技术》2015年06期 　论文类型：期刊论文

【摘要】：采用喷雾干燥工艺制备枸橼酸喷托维林微粉,设计正交实验分析各工艺参数对微粉粒度分布的影响,优化工艺条件;利用X射线衍射与扫描电子显微镜表征微粉的微观结构和微观形貌,分析化合物的结晶过程。结果表明:枸橼酸喷托维林微粉最佳喷雾干燥工艺条件是料液中药物的质量浓度为0.03 g/m L,入口温度为170℃,进液速率为400 m L/h;喷雾干燥过程中,料液中悬浊颗粒物相结构不发生改变,微观形貌呈片状;溶质状态药物在固-液界面处晶态生长,或以非晶态析出,后者微观形貌主要为球形颗粒。
[Abstract]:Spray drying technology was used to prepare Topeverine citrate powder. Orthogonal experiment was designed to analyze the effect of process parameters on particle size distribution and optimize the process conditions. The microstructure and morphology of the powder were characterized by X-ray diffraction and scanning electron microscope. The results showed that the optimum spray drying conditions were 0.03 g / mL, 170 鈩，

本文编号：1537180