阿司匹林抵抗的研究现状及工作启示

发布时间：2018-03-01 09:35

本文关键词： 阿司匹林抵抗临床药师发生机制血小板功能检测方法个体化用药　出处：《中国药学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的阿司匹林抵抗现象备受临床关注,药物抵抗的产生增加了缺血性事件的发生率和死亡率。为促进临床合理用药,降低不良反应的发生风险,临床药师需对阿司匹林抵抗的研究现状进行了解。方法笔者以"阿司匹林"、"抵抗"等为关键词,通过检索Pubmed、CNKI及万方数据库,筛选近5年发表的与阿司匹林抵抗的定义、发生机制及检测方法有关的国内外文献,以全面了解这一现象的研究现状。结果目前,"阿司匹林抵抗"的定义尚不明确,研究者多侧重从分子生物学角度探讨其发生机制。现有的血小板功能检测方法多种多样、各有利弊,大大增加了临床选择难度。结论临床药师只有在充分了解其研究现状的基础上,结合学科背景,才能把握后续研究的突破口,全面评估和解读实验室检测数据,为个体化用药提供帮助。
[Abstract]:Objective to increase the incidence and mortality of ischemic events and decrease the risk of adverse reactions in order to promote rational drug use, aspirin resistance has attracted much attention in clinical practice, and the occurrence of drug resistance has increased the incidence and mortality of ischemic events. Methods the authors used "aspirin" and "resistance" as the key words to search the database of Pubmedan CNKI and Wanfang to screen the definitions of aspirin resistance published in the past 5 years. In order to fully understand the present situation of this phenomenon, the definition of "aspirin resistance" is not clear at present. The present methods of platelet function detection are various and have advantages and disadvantages. Conclusion only on the basis of fully understanding the current research situation and combining with the background of the subject, the clinical pharmacists can grasp the breakthrough of the follow-up research and comprehensively evaluate and interpret the laboratory test data. To provide assistance for individualized medication.
【作者单位】：中国医学科学院北京协和医学院北京协和医院药剂科;中国医学科学院北京协和医学院北京协和医院神经科;
【分类号】：R96

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