我院抗肿瘤药物合理应用评价体系的建立及实施效果评价

发布时间：2018-03-02 06:38

本文关键词： 抗肿瘤药物合理用药评价指标临床药师德尔菲法　出处：《中国药房》2017年29期 　论文类型：期刊论文

【摘要】：目的:构建我院抗肿瘤药物合理应用评价体系并评价其实施效果。方法:结合我院2014年1-10月1 927例恶性肿瘤患者的病历,采用德尔菲法确定评价指标;查阅国内外权威指南、相关文献和药品说明书等,按照循证药学方法从化疗方案、给药剂量、药物预处理、溶剂选择、给药浓度、给药频次等6个方面入手,构建我院抗肿瘤药物合理应用评价体系。选取我院2015年5月(干预前组,98例)、12月(干预后组,87例)肿瘤化疗患者,以上述体系为标准进行专项点评,比较干预前后两组患者抗肿瘤药物的使用情况。结果:干预前组患者的抗肿瘤药物不合理使用率为62.2%,干预后组为29.9%;其中给药剂量、药物预处理、给药浓度、化疗方案的不合理率分别由30.6%、21.4%、8.2%、6.1%下降至12.6%、6.9%、4.6%、2.3%,差异均有统计学意义(P0.05);但溶剂选择和给药频次不合理使用情况未能得到明显改善,差异均无统计学意义(P0.05)。结论:通过建立抗肿瘤药物合理应用评价体系,能够较好地改善我院抗肿瘤药物的不合理使用现象,具有一定的可行性,可为临床药师规范抗肿瘤药物的临床使用提供参考。
[Abstract]:Objective: to construct the evaluation system of rational application of antitumor drugs and evaluate its effect in our hospital. Methods: according to the medical records of 1,927 patients with malignant tumor from 2014 to October in our hospital, the evaluation index was determined by Delphi method, and the authoritative guidelines at home and abroad were consulted. Relevant literature and drug instructions, according to evidence-based pharmaceutical methods, from the chemotherapy program, dosage, drug pretreatment, solvent selection, drug concentration, administration frequency and other six aspects, The evaluation system of rational use of antineoplastic drugs in our hospital was established. 98 cases of cancer chemotherapy were selected in our hospital on May 2015 (pre-intervention group) and December (post-intervention group (87 cases)). Results: the irrational utilization rate of antitumor drugs was 62.2 in the pre-intervention group and 29.9 in the post-intervention group. The unreasonable rate of chemotherapy regimen decreased from 30.6% to 12.66.9and 4.60.2.3The difference was statistically significant, but the irrational use of solvent selection and administration frequency could not be significantly improved. Conclusion: the establishment of evaluation system for the rational use of antitumor drugs can improve the irrational use of antitumor drugs in our hospital. It can provide reference for clinical pharmacists to standardize the clinical use of anti-tumor drugs.
【作者单位】：山西晋城无烟煤矿业集团有限责任公司总医院药学部;
【分类号】：R95

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