新疆维吾尔族患者CYP2C9和VKORC1基因多态性分布及不同种族间的比较

发布时间：2018-03-03 21:28

本文选题：维吾尔族　切入点：基因多态性　出处：《中国药房》2015年24期 　论文类型：期刊论文

【摘要】：目的:为建立适合新疆维吾尔族患者的华法林个体化给药模型提供研究基础。方法:检测200例新疆维吾尔族患者中CYP2C9和VKORC1的基因型,并与世界不同种族人群基因型及等位基因频率进行比较。结果:新疆维吾尔族CYP2C9*1/*1基因型频率低于韩国、日本、美国及中国汉族,高于土耳其;*1/*2杂合突变型频率低于土耳其、瑞典、英国,高于韩国、日本及中国汉族;*1/*3杂合突变型频率高于日本、韩国、中国汉族、英国、美国;*3/*3基因频率高于上述人群(P0.05)。新疆维吾尔族*1等位基因频率低于中国汉族、日本、韩国、美国,高于土耳其;*2等位基因高于中国汉族、日本、韩国,低于土耳其、瑞典、英国;*3等位基因高于中国汉族、日本、韩国、瑞典、英国和美国(P0.05)。VKORC1-1639AA型频率高于美国、瑞典、英国,低于新加坡、日本、中国台湾、中国汉族;AG型频率高于新加坡、日本、中国台湾、中国汉族;GG型频率高于新加坡、日本、中国台湾、中国汉族,低于美国、瑞典、英国(P0.05)。新疆维吾尔族A型等位基因频率低于中国汉族、中国台湾、日本、新加坡,高于美国、瑞典和英国;G型等位基因高于中国汉族、中国台湾、日本、新加坡,低于美国、瑞典、英国(P0.05)。结论:新疆维吾尔族患者CYP2C9和VKORC1基因多态性分布与亚洲及欧美人群均存在明显差异。
[Abstract]:Objective: to provide a basis for the establishment of an individual administration model of warfarin in Xinjiang Uygur patients. Methods: the genotypes of CYP2C9 and VKORC1 were detected in 200 Xinjiang Uygur patients. Results: the frequency of CYP2C9*1/*1 genotype in Xinjiang Uygur population was lower than that in Korea, Japan, USA and Han nationality, and the frequency of heterozygous mutation in Xinjiang Uygur population was lower than that in Turkey. The frequency of heterozygous 1 / 3 heterozygosity in Sweden, Britain, Korea, Japan and Chinese Han nationality is higher than that in Japan, Korea, China, Han nationality, Britain and the United States, and is higher than that in the above population (P0.05A). The frequency of allele 1 in Xinjiang Uygur nationality is lower than that in Han nationality in China. The alleles in Japan, Korea, USA, and Turkey are higher than those in Han nationality, Japan, Korea, Turkey, Sweden, UK, Japan, Korea, Sweden, Japan, Japan, Korea, Sweden, Japan, Japan, Korea, Sweden. The frequency of P0.05U. VKORC1-1639AA in the United Kingdom and the United States is higher than that in the United States, Sweden, the United Kingdom, lower than Singapore, Japan, Taiwan, China, Han nationality, and the frequency of AG type AG is higher than that in Singapore, Japan, Taiwan, China, Han nationality, the frequency of GG is higher than that in Singapore and Japan. The allele frequency of type A in Xinjiang Uygur nationality is lower than that in Han nationality in China, and in Taiwan, Japan, Singapore, China, USA, Sweden and UK, the allele frequency of type A in Xinjiang Uygur is higher than that in Han nationality of China. China Taiwan, Japan, Singapore, lower than the United States, Sweden, Britain P0.055.Conclusion: the distribution of CYP2C9 and VKORC1 gene polymorphisms in Xinjiang Uygur patients is significantly different from those in Asia, Europe and America.
【作者单位】：新疆医科大学第一附属医院药学部;
【基金】：新疆医科大学第一附属医院院内科研基金项目(No.2013ZRQN21)
【分类号】：R969

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