药源性过敏性休克和严重过敏样反应报告分析

发布时间：2018-03-05 08:46

本文选题：药源性急性严重过敏反应　切入点：药源性过敏性休克　出处：《中国临床药理学杂志》2015年19期 　论文类型：期刊论文

【摘要】：目的了解北京大学第三医院药源性过敏性休克(DIAS)和严重过敏样反应(DIAR)的致敏药物类型及过敏反应的发生情况(包括临床表现、救治方案及预后等)。方法筛选北京大学第三医院2004-01-01—2014-12-31上报国家药品不良反应监测系统的DIAS和DIAR报告,对纳入报告患者的一般情况、致敏药物类型、临床表现、治疗方案及转归等资料进行分析。结果共纳入69份不良反应报告,男女比例为1.00∶1.56,以速发型超敏反应为主(85.5%),最常见的致敏药物为抗菌药物(45.5%),临床症状主要表现为心血管系统(92.8%)、呼吸系统(58.0%)和皮肤黏膜系统(58.0%)受累。在DIAS和DIAR救治中,糖皮质激素(58.0%)、补液治疗(53.6%)以及抗过敏药物治疗(40.6%)最为常见。69份不良反应报告中,经救治后痊愈29例(42.0%),好转37例(53.6%),死亡、住院治疗、数据缺失各1例(1.4%)。结论 DIAS与DIAR占全部报告的2.5%(69/2761),由于其存在不可预测性,对患者危害较大,建立规范的救治及预防措施具有重要意义。
[Abstract]:Objective to investigate the types of drug sensitizers and the occurrence of allergic reactions (including clinical manifestations) in Dish and DIAR in the third Hospital of Peking University. Methods the DIAS and DIAR reports were selected from the third Hospital of Peking University from January 1 to 31, 2004 to report to the National adverse Drug reaction Surveillance system. The general situation of the patients included in the report, the types of sensitized drugs, and the clinical manifestations were analyzed. The data of treatment plan and outcome were analyzed. Results 69 ADR reports were included. The ratio of male to female was 1.00: 1.56, with a rapid hypersensitivity rate of 85.55.The most common allergen was the antimicrobial drug, 45.5%. The main clinical symptoms were the cardiovascular system (92.880%) and the respiratory system (58.0%) and the skin and mucosal system (58.0%). In the treatment of DIAS and DIAR, Of the 69 reports of adverse reactions, 29 cases were cured after treatment, 37 cases were cured and 53.6% were cured, 37 cases were cured, 53.6% died, and were hospitalized. Conclusion DIAS and DIAR account for 2.569 / 2761% of the total reported data. Because of their unpredictability, they are harmful to patients. It is of great significance to establish standard treatment and prevention measures.
【作者单位】：北京大学第三医院药剂科;
【基金】：卫生部临床重点专科建设项目(56495-04)
【分类号】：R595.3

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