某三甲医院100例住院患者万古霉素临床应用分析

发布时间：2018-03-06 04:07

本文选题：万古霉素　切入点：临床应用　出处：《中国药师》2016年12期 　论文类型：期刊论文

【摘要】：目的:调查评价某院万古霉素临床使用情况,为促进万古霉素的合理应用提供参考。方法:采用回顾性研究方法,调查某院2015年9月~2016年2月使用万古霉素的100例住院患者病历资料,对药品的使用情况、病原学检查及血药浓度监测等情况进行统计汇总,并根据按有关指南制定的"万古霉素应用合理性评价标准"进行用药合理性评估,对用药不合理情况进行分类统计分析。结果:100例使用万古霉素住院患者,男性61%,女性39%,平均年龄(55.69±19.88)岁;治疗有效率为81%;发生不良反应1例(1%);药物利用指数DUI为0.66;微生物标本送检率为69.4%,根据药敏结果选用万古霉素23例;进行血药浓度监测15例(占15%),对其中6例血药浓度20μg·ml~(-1)者进行剂量调整;给药方案基本合理,但有疗程不合理者11例;不合理使用万古霉素20例(占20%)。结论:该院万古霉素使用基本合理,不存在过度使用现象。但仍存在某些不适宜用药问题。
[Abstract]:Objective: to investigate and evaluate the clinical use of vancomycin in a hospital, and to provide a reference for the rational application of vancomycin. The medical records of 100 inpatients who used vancomycin from September 2015 to February 2016 in a hospital were investigated. The data of drug use, etiological examination and blood drug concentration monitoring were collected. According to the criteria for evaluating the rationality of vancomycin application, the rationality of the use of vancomycin was evaluated, and the unreasonable situation of the drug was classified and analyzed. Results: one hundred hospitalized patients with vancomycin were treated with vancomycin. Male 61g, female 39g, mean age 55.69 卤19.88 years; effective rate 81yr; adverse reaction 1 case; drug utilization index 0.66; microorganism sample 69.4d; vancomycin 23 cases according to drug sensitivity results; Blood drug concentration monitoring was carried out in 15 cases (15 / 15), in which 6 cases (20 渭 g 路ml ~ (-1)) were dose-adjusted. Conclusion: the use of vancomycin in this hospital is basically reasonable and there is no phenomenon of overuse, but there are still some unsuitable problems in the use of vancomycin.
【作者单位】：南京市第三医院药剂科;南京医科大学第二附属医院药剂科;南京医科大学药学院;
【分类号】：R978.1

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