某院2009例药品不良反应报告回顾性分析

发布时间：2018-03-06 15:08

本文选题：药品不良反应　切入点：回顾分析　出处：《中国医院药学杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的:分析我院2009例药品不良反应(ADR)报告的发生特点,提取并发现风险信号,为优化药品安全性监测模式,促进临床合理用药提供参考。方法:以《WHO不良反应术语集》、《药品不良反应报告和监测管理办法》、《药品不良反应因果关系评价表》等为标准,采用回顾性调查研究方法,对2009例有效ADR报告中患者年龄、给药途径、严重ADR涉及药物种类、ADR累及器官/系统、监测上报人员类型等数据进行分类汇总和统计分析。结果:2009例有效ADR报告中,60岁以上患者ADR的发生比例为34.15%,14岁及以下患者ADR的发生比例为7.22%;静脉滴注给药途径ADR的发生例数最高,肌肉注射给药途径ADR的发生例数最低。ADR涉及药物品种主要为心血管系统药物、抗微生物药物和抗肿瘤药物;ADR临床表现以全身性损害最为常见,其次分别是皮肤及其附件损害和中枢及外周神经系统损害;ADR报表上报人员以医师为主,占比为87.11%,药师上报例数最低,占比为0.99%;严重ADR主要涉及抗肿瘤药物、诊断用药(造影剂)和抗微生物药物。结论:在ADR日常监测过程中,抗感染药物、心血管药物及抗肿瘤药物是ADR监测重点药物类别,60岁以上和14岁及以下的患者是ADR监测重点人群,静脉滴注给药途径是ADR监测重点给药途径,皮肤及其附件病变是提示ADR发生的重要信号。临床ADR监测应重点关注上述影响因素,结合患者具体情况,实施个体化给药,进一步提高临床合理用药水平,确保患者用药安全。
[Abstract]:Objective: to analyze the occurrence characteristics of ADR2009 cases of adverse drug reactions in our hospital, extract and find out the risk signals, and optimize the drug safety monitoring model. Methods: according to the criteria of "WHO adverse reaction terminology set", "adverse Drug reaction report and Monitoring Management method", "adverse Drug reaction causality Evaluation Table", and so on, retrospective investigation and research methods were used. The age of the patients reported in the effective ADR report in 2009, the route of administration, and the serious ADR were involved in organ / system involvement. Results the incidence rate of ADR in patients over 60 years of age was 34.15 years old and under 14 years old, and the incidence rate of ADR was 7.22%. Has the highest number of occurrences, The incidence of ADR by intramuscular injection was the lowest. The drugs involved were mainly cardiovascular drugs. The clinical manifestations of anti-microbial drugs and anti-tumor drugs were the most common. Secondly, the report reports of skin and its adnexal damage and central and peripheral nervous system damage were mainly reported by doctors (87.11%), the pharmacists reported the lowest number of cases (0.99%), severe ADR mainly involved anti-tumor drugs, and the number of cases reported by pharmacists was the lowest (0.99%), and severe ADR was mainly related to anti-tumor drugs. Diagnostic drugs (contrast agents) and antimicrobial agents. Conclusion: during the routine monitoring of ADR, antiinfective drugs, Cardiovascular drugs and antitumor drugs were the key drug types of ADR monitoring. Patients aged over 60 years old and 14 years old and under 14 years old were the key population of ADR monitoring. Intravenous drip was the key drug delivery route of ADR monitoring. The skin and its adnexal lesions are important signals for the occurrence of ADR. Clinical ADR monitoring should focus on the above influencing factors and carry out individualized administration of drugs in combination with the specific conditions of patients to further improve the level of rational use of drugs in clinical practice and ensure the safety of drug use in patients.
【作者单位】：新疆医科大学第一附属医院;新疆医科大学;
【基金】：新疆医科大学人文社会科学基金项目(药物警戒信号对医院安全用药警示作用的研究,项目编号2014XYDSK46)
【分类号】：R95

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