当归小分子多糖对血管性痴呆大鼠学习与记忆功能的影响

发布时间：2018-03-09 19:15

本文选题：当归小分子多糖　切入点：血管性痴呆　出处：《中国临床药理学杂志》2015年11期 　论文类型：期刊论文

【摘要】：目的观察当归小分子多糖对血管性痴呆模型大鼠学习与记忆功能的影响。方法动物随机分为6组:假手术组、模型组、对照组;3个剂量当归小分子多糖组。用颈内动脉注射血栓的方法制作血管性痴呆大鼠模型,当归小分子多糖低、中、高3个剂量组分别腹腔注射当归小分子多糖0.08,0.15,0.30 g·kg-1,对照组腹腔注射血栓通注射液42 mg·kg-1,模型组和假手术组动物分别腹腔注射等量0.9%氯化钠,每天1次,共28 d。用Morris水迷宫实验观察当归小分子多糖对实验动物学习及记忆功能的影响,并观察大鼠脑Tau蛋白的表达。结果当归小分子多糖能明显缩短大鼠的逃避潜伏期,增加停留原平台位置时间;当归小分子多糖中、大2个剂量组大鼠脑总Tau蛋白表达明显下降。结论当归小分子多糖可改善血管性痴呆大鼠的学习及记忆功能,其机制可能与抑制Tau蛋白表达的有关。
[Abstract]:Objective to observe the effect of Angelica sinensis small molecule polysaccharide on learning and memory in vascular dementia rats. Methods the rats were randomly divided into six groups: sham operation group and model group. Control group; three doses of Angelica sinensis small molecule polysaccharide group. Vascular dementia rat model was made by internal carotid artery injection of thrombus. The rats in the high dose group were given intraperitoneal injection of Angelica sinensis small molecular polysaccharide 0.08 ~ 0.15g 路kg ~ (-1), the control group was given 42 mg 路kg ~ (-1) Xue Tong injection, and the model group and the sham operation group were respectively injected with the same amount of 0.9% sodium chloride once a day. The effects of Danggui small molecule polysaccharide on learning and memory function and the expression of Tau protein in rat brain were observed by Morris water maze test. Results the escape latency of rats was significantly shortened by Danggui small molecule polysaccharide. The expression of total Tau protein in rat brain was significantly decreased in the two dose groups. Conclusion Danggui small molecular polysaccharide can improve the learning and memory function of vascular dementia rats. The mechanism may be related to the inhibition of Tau protein expression.
【作者单位】：武汉大学中南医院药剂科;武汉市洪山区中医院药剂科;
【分类号】：R965

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