甲氨蝶呤致药物超敏反应综合征案例报道及文献分析

发布时间：2018-03-11 16:08

本文选题：甲氨蝶呤　切入点：药物超敏反应综合征　出处：《中国新药杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:探讨甲氨蝶呤致药物过敏反应的临床特点,为该药的安全合理使用提供依据。方法:报道我院1例甲氨蝶呤致药物超敏反应综合征案例,并通过检索Medline,CNKI,万方、维普等数据库,收集甲氨蝶呤致过敏反应相关文献报道,进行统计分析。结果:综合文献及我院案例,共收集38例甲氨蝶呤致过敏反应病例,以18岁以下未成年患者居多,原发疾病以骨肉瘤和急性淋巴细胞白血病为主,给药方式主要为静脉滴注,临床表现多为系统性过敏症状。除3例患者死亡外,其余均症状缓解,并有5例患者经脱敏治疗后继续使用甲氨蝶呤。结论:甲氨蝶呤相关过敏反应发生率虽低但严重程度较高,临床应用时需密切关注患者的病情变化,及时采取应对措施。对发生甲氨蝶呤过敏反应又须继续用药的患者,可尝试脱敏治疗。
[Abstract]:Objective: to investigate the clinical characteristics of methotrexate induced drug hypersensitivity, and to provide evidence for the safe and rational use of methotrexate. Methods: a case of methotrexate induced drug hypersensitivity syndrome was reported in our hospital. Results: a total of 38 cases of methotrexate induced allergic reaction were collected in our hospital. The primary diseases were osteosarcoma and acute lymphoblastic leukemia. The main way of administration was intravenous drip. The clinical manifestations were mostly systemic hypersensitivity. Five patients continued to use methotrexate after desensitization. Conclusion: the incidence of methotrexate related allergic reaction is low but the severity is high. Timely response. Patients with methotrexate hypersensitivity and need to continue medication, can try desensitization treatment.
【作者单位】：北京大学人民医院药剂科;
【基金】：国家自然科学基金资助项目(81503050)
【分类号】：R977

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