提高水溶性药物稳定性的新型技术研究进展

发布时间：2018-03-12 08:14

本文选题：水溶性药物　切入点：稳定性　出处：《中国药房》2017年07期 　论文类型：期刊论文

【摘要】：目的:为水溶性药物研发提供新思路和理论支持。方法:以"水溶性药物""稳定性""平衡离子""Water-soluble drugs""Stability""Counter ion"等为关键词,组合查询2007年1月-2016年7月在Pub Med、Elsevier、Springer Link、中国知网、万方、维普等数据库中的相关文献,对平衡离子成盐技术、聚乙二醇(PEG)修饰技术、药物分子框架技术和脂质体技术等提高水溶性药物稳定性的新型技术进行综述。结果与结论:共检索到相关文献118篇,其中有效文献39篇。平衡离子对药物稳定性有重要作用,其中通过使药物成盐是其重要手段之一;PEG修饰技术在提高药物稳定性方面也有重要作用,经PEG修饰的药物已有多个获批上市,证明了PEG修饰是有效可行的药物载体;药物分子框架技术能对药物产生较强的保护作用,是一类颇有潜力的改进药物稳定性的重要材料,目前在医药领域已取得了可观的成果;脂质体技术能够有效地提高药物的稳定性和利用率,具有广阔的应用前景。
[Abstract]:Objective: to provide new ideas and theoretical support for the research and development of water-soluble drugs. Methods: taking "water-soluble drugs", "stability", "equilibrium ions", "Water-soluble drugs," "Stability", "Counter ion" and so on, as keywords, the authors made a combination inquiry at Pub Medde Elsevier Springer Link, China Zhiwang, Wanfang, from January 2007 to July 2016. Related literature in database such as Wiper, salt forming technology of equilibrium ion, polyethylene glycol peg modification technology, Results and conclusion: 118 related papers were retrieved, of which 39 were effective. Equilibrium ion plays an important role in drug stability. Among them, PEG modification plays an important role in improving the stability of drugs by halogenation. PEG modification has been approved and listed, which proves that PEG modification is an effective and feasible drug carrier. Drug molecular framework technology can produce strong protective effect on drugs, and it is a kind of important material with great potential to improve drug stability. At present, considerable achievements have been made in the field of medicine. Liposome technology can effectively improve the stability and utilization of drugs, and has a broad application prospect.
【作者单位】：黑龙江中医药大学药学院;
【分类号】：R94

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