高脂血症大鼠给予绞股蓝和阿托伐他汀前后脂肪酸成分分析

发布时间：2018-03-12 22:42

  本文选题：绞股蓝　切入点：阿托伐他汀　出处：《沈阳药科大学学报》2015年05期 　论文类型：期刊论文

【摘要】：目的对高脂血症大鼠给予绞股蓝和阿托伐他汀前后脂肪酸成分进行分析,探讨两种药物治疗高脂血症的机制。方法采用GC-MS法对高脂血症大鼠及给药前后血浆和肝组织脂肪酸代谢物进行分析,应用ELISA法对体内炎症因子TNF-α和IL-6的含量进行测定。结果高脂血症大鼠体内C18∶1/C18∶0及C16∶1/C16∶0含量的比值下降,∑n-6/n-3脂肪酸含量的比值与炎症因子TNF-α、IL-6的含量升高。给予中药绞股蓝后,∑n-6/n-3脂肪酸含量的比值与炎症因子的含量得到恢复,给予西药阿托伐他汀后均没有变化。结论中药绞股蓝能更有效地使体内脂肪酸成分得以恢复,其效果优于阿托伐他汀。
[Abstract]:Objective to analyze the fatty acid composition of gynostemma pentaphyllum and Atto vastatin in hyperlipidemic rats. Methods GC-MS method was used to analyze the fatty acid metabolites in plasma and liver tissue of hyperlipidemic rats before and after administration. Results the ratio of C18: 1 / C18: 0 and C16: 1 / 1 / C16: 0 in hyperlipidemia rats was decreased, and the ratio of 鈭，

本文编号：1603599