基因多态性对麦考酚酸及其代谢产物药动学影响的研究进展

发布时间：2018-03-16 16:53

本文选题：基因多态性　切入点：麦考酚酸　出处：《中国医院药学杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的:综述近年来国内外学者对基因多态性与麦考酚酸(MPA)及其代谢产物药动学关系的研究,为指导临床合理用药提供循证依据。方法:查阅国内外相关文献,进行系统的文献整理和综合分析。结果:各研究间由于研究对象的病理生理差异、种族差异、突变频率不同、合并用药的影响等,研究结果存在差异。其中,可能与MPA及其代谢产物药动学有关的位点有:UGT2B7 C802T、SLCO1B3 T334G、UGT1A9 T-275A/或C-2152T;存在争议的位点有:UGT1A8*2、UGT1A9 I399C/T、UGT1A9 C-440T、ABCC2 C-24T、ABCG2 C421A;可能无关的位点有:CES2、SLCO1B1、SLCO2B1、ABCB1 C3435T。结论:基因多态性可以影响MPA及其代谢产物的药动学,要进一步阐明基因多态性与MPA及其代谢产物药动学的关系,尚需更多高质量、大样本的体内研究。
[Abstract]:Objective: to review the recent studies on the relationship between gene polymorphism and mycophenolic acid (MPA) and its metabolite pharmacokinetics, and to provide evidence-based evidence for guiding rational drug use in clinical practice. Methods: the relevant literature at home and abroad was reviewed. A systematic literature review and comprehensive analysis were carried out. Results: there were differences in the results of the studies due to the pathophysiological differences, ethnic differences, mutation frequencies and the effects of combined use of drugs. The possible sites associated with MPA and its metabolites pharmacokinetic are: UGT2B7 C802TnSLCO1B3 T334GUGT1A9 T-275A9 or C-2152T; disputed loci UGT1A8A9 I399C / TUGT1A9 C-440TABCC2 C-24TnABCG2C421A; perhaps unrelated loci: CES2SLCO1B1B1ABB1ABCB1SLC3435T.Conclusion: genetic polymorphisms may affect the pharmacokinetics of MPA and its metabolites. In order to further elucidate the relationship between gene polymorphism and pharmacokinetics of MPA and its metabolites, more high quality and large sample in vivo studies are needed.
【作者单位】：南京军区福州总医院药学科;沈阳药科大学药学院;
【分类号】：R969

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