制备卡铂缓释微粒的材料及应用研究进展

发布时间：2018-03-17 11:27

  本文选题：卡铂　切入点：缓释　出处：《中国药房》2017年34期 　论文类型：期刊论文

【摘要】：目的:为选择制备卡铂缓释微粒的材料提供参考。方法:以"卡铂""缓释""微粒""Carboplatin""Release""Microparticle"等为关键词,组合查询1997年1月-2017年4月在中国知网、Pub Med、Web of Science、Elsevier等数据库中的相关文献,对常用的制备卡铂缓释微粒的材料特点、制备方法及国内外相关研究等方面进行综述。结果与结论:共检索到相关文献193篇,其中有效文献26篇。常用的制备卡铂缓释微粒的材料有聚乳酸-羟基乙酸共聚物(PLGA)、聚己内酯(PCL)、明胶、海藻酸盐/壳聚糖及其他材料。PLGA的降解时间可通过改变丙交酯和乙交酯的比例使其从几天变到几年,可通过更复杂的表面修饰使PLGA微粒的靶向性更强、到达靶器官的药物浓度更高。但PLGA的制备方法目前难以应用于大规模的生产,其重现性和稳定性还有待提高。PCL不仅可主动和被动地靶向肿瘤组织,而且能避免卡铂给药的溶血副作用。但PCL目前的研究均是在体外及动物体内进行,进入人体的研究相对较少。明胶材料的优点包括易乳化、水溶性、成膜、弹性和天然可生物降解,然而其微粒普遍表现出突释现象,想要制备出缓释性能更好的传递系统,需要与其他材料联合应用。海藻酸钠/壳聚糖微粒能有效地保留高分子的生物活性,作为负载各种药剂及食品抗菌剂的包埋材料在医药、食品工业和化妆品等领域中具有良好的应用前景。但对于卡铂的包载,其受到氯离子的影响,包封率较低。虽然每种缓释材料的特性不同,对卡铂的包载程度不一,但制备出的缓释微粒均比卡铂溶液具有更稳定的化学性质、更长的缓释时间、更强的靶向作用以及更低的全身毒性。今后应从卡铂缓释微粒载药量和包封率的进一步提高、药物释放速率及缓释时间的精确控制、缓释体系的表面改性及多种缓释体系的联合应用等方面进行深入研究。
[Abstract]:Objective: to provide a reference for the selection of materials for the preparation of carboplatin sustained release particles. Methods: taking "carboplatin", "sustained release", "Carboplatin", "Release", "Microparticle" and so on as keywords, the relevant documents in the database Pub Meden of Scienceof Science Elsevier from January 1997 to April 2017 were searched. The material characteristics, preparation methods and related research of carboplatin sustained-release particles were reviewed. Results and conclusion: 193 related literatures were retrieved. The commonly used materials for preparation of carboplatin sustained-release particles are poly (lactic acid-glycolic acid) (PLGA), polycaprolactone (PCL), gelatin, polycaprolactone (PCL), polycaprolactone (PCL) and gelatin. The degradation time of alginate / chitosan and other materials. PLGA can be changed from a few days to a few years by changing the ratio of lactide to glycolide, and the targeting of PLGA particles can be enhanced by more complex surface modification. However, the preparation method of PLGA is difficult to be used in large-scale production, and its reproducibility and stability need to be improved. In addition, the hemolytic side effects of carboplatin administration can be avoided. However, the current studies of PCL are carried out in vitro and in vivo, but relatively few studies have been carried out into human body. The advantages of gelatin materials include easy emulsification, water solubility and membrane formation. Elastic and naturally biodegradable, however, the particles generally exhibit sudden release, and they want to produce a delivery system with better slow-release properties. Sodium alginate / chitosan particles can effectively retain the biological activity of polymers and are used as encapsulation materials for various pharmaceutical and food antimicrobial agents. Food industry, cosmetics and other fields have good application prospects. However, for carboplatin encapsulation, it is affected by chloride ions, and the encapsulation efficiency is low. Although the properties of each kind of sustained-release materials are different, the degree of encapsulation of carboplatin varies. However, the prepared slow-release particles have more stable chemical properties, longer sustained release time, stronger targeting effect and lower systemic toxicity than carboplatin solution. In the future, the drug loading and encapsulation efficiency of carboplatin slow-release particles should be further increased. The precise control of drug release rate and release time, the surface modification of sustained release system and the combined application of several slow release systems were studied in detail.
【作者单位】： 吉林大学口腔医院修复科;吉林大学第二医院妇产科;
【基金】：吉林省科技发展计划项目(No.20140311088YY、20150204004YY、201603028YY) 长春市科技计划项目(No.14KG049、16ss12)
【分类号】：R943
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本文编号：1624539