多球壳菌素延长裂殖酵母细胞寿命可能机制研究

发布时间：2018-03-18 11:01

本文选题：裂殖酵母　切入点：多球壳菌素　出处：《天然产物研究与开发》2017年06期 　论文类型：期刊论文

【摘要】：寻找抗衰老活性分子并研究其作用机制是衰老药物学的研究重点和热点。前期研究发现天然产物多球壳菌素(一种神经鞘脂合成特异性抑制剂)能够延长模式生物芽殖酵母的寿命,而裂殖酵母在进化上更接近哺乳动物,且在形态和遗传上与芽殖酵母有显著差异的另一种模式生物,本研究考察了多球壳菌素对裂殖酵母寿命的影响,并进一步研究了其调控细胞寿命的相关机制。结果显示,多球壳菌素延长裂殖酵母寿命具有保守性,其延长细胞寿命的机制包括:增强细胞压力抗性、促进糖原和海藻糖的积累、降低胞内活性氧的水平,且发现多球壳菌素介导的寿命延长依赖于压力应答类蛋白激酶Sty1。综上,多球壳菌素是一种潜在的抗衰老药物分子,后期有望开发它用于延缓哺乳动物细胞(包括人类)衰老及预防和治疗衰老相关疾病。
[Abstract]:Searching for anti-aging active molecules and studying the mechanism of their action are the focus and hotspot of aging pharmacology. Previous studies have found that the natural product, a specific inhibitor of sphingolipid synthesis, can prolong the model generation. The longevity of budding yeast, But another model organism, which is more similar to mammalian in evolution and has significant difference in morphology and heredity with budding yeast, was studied to study the effect of globulin on the lifespan of merozoite yeast. The results showed that the prolongation of the lifespan of merozoite yeast was conserved, and the mechanisms of prolonging cell life included enhancing cell stress resistance. To promote the accumulation of glycogen and trehalose, to reduce the level of intracellular reactive oxygen species, and to find that the prolongation of life span mediated by polyglobulin depends on pressure responsive protein kinase Sty1.In summary, polyglobulin is a potential antiaging drug molecule. It is expected to be developed later on to delay the aging of mammalian cells, including humans, and to prevent and treat aging related diseases.
【作者单位】：西南交通大学生命科学与工程学院;
【基金】：四川省科技厅应用基础研究项目(2016JY0113) 成都市科技局科技惠民计划(2015-HM01-00047-SF) 中央高校基本科研业务费科技创新项目(2682016 CX099) 中国大学生科研训练项目(201510613061)
【分类号】：R96

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