姜黄素纳米混悬剂制备及体外溶出度研究

发布时间：2018-03-20 18:30

本文选题：姜黄素　切入点：纳米混悬剂　出处：《辽宁中医药大学学报》2016年12期 　论文类型：期刊论文

【摘要】：目的:制备姜黄素纳米混悬剂,并研究其体外溶出度。方法:采用高压均质法制备姜黄素纳米混悬剂,以纳米混悬剂粒径分布、Pd I和Zeta电位为指标,考察了姜黄素纳米混悬剂的影响因素,对制得的纳米混悬剂进行表征,并比较姜黄素纳米混悬剂溶液、固化纳米混悬剂和原料药的溶出速率和溶出量。结果:姜黄素纳米混悬剂平均粒径为(396.4±67.2)nm,Pd I为(0.369±0.061),Zeta电位为(-16.7±3.5)m V;扫描电镜显示纳米混悬剂粒径均一。姜黄素纳米混悬剂溶液和固化姜黄素纳米混悬剂的体外累积溶出度明显高于姜黄素原料药。结论:高压均质法制备姜黄素纳米混悬剂的工艺简单易行,姜黄素纳米混悬剂能显著提高药物的体外溶出度。
[Abstract]:Objective: to prepare curcumin nano-suspension and study its dissolution in vitro. Methods: curcumin nano-suspension was prepared by high pressure homogenization method. The particle size distribution of curcumin nano-suspension was determined by PD I and Zeta potential. The influence factors of curcumin nano-suspension were investigated, the prepared nano-suspension was characterized, and the curcumin nano-suspension solution was compared. Results: the average particle size of curcumin nano-suspension was 396.4 卤67.2 nmdI, the Zeta potential of curcumin nano-suspension was 0.369 卤0.061, the Zeta potential of curcumin nano-suspension was -16.7 卤3.5mV, scanning electron microscope showed that the particle size of nano-suspension was the same and curcumin nano-suspension was the same as that of curcumin nano-suspension, the average particle size of curcumin nano-suspension was 396.4 卤67.2nmdI, and the Zeta potential of curcumin nano-suspension was -16.7 卤3.5mV. The cumulative dissolution of curcumin nano-suspension and curcumin nano-suspension in vitro was significantly higher than that of curcumin raw material. Conclusion: the preparation of curcumin nano-suspension by high-pressure homogenization is simple and feasible. Curcumin nano-suspension can significantly improve the dissolution of drugs in vitro.
【作者单位】：陕西中医药大学;咸阳职业技术学院;
【基金】：陕西省科技厅计划项目(2015SF203) 陕西省中药制药重点学科资助项目
【分类号】：R943

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