我国心血管药物不良反应中英文本体构建与知识发现研究

发布时间：2018-03-21 23:05

本文选题：心血管药物　切入点：药物不良反应　出处：《吉林大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:构建我国心血管药物不良反应中英文本体知识库,系统性表示心血管药物不良反应,为心血管药物不良反应的系统性分析与知识发现提供资源、奠定基础;基于本体分析心血管药物不良反应发生模式;开发数据挖掘算法对药物引起不良反应的类效应进行知识发现。方法:根据我国《新编药物学》(第17版)在相关网站收集我国目前使用的心血管药物,收集心血管药物说明书,提取药品说明书中的药物和不良反应信息并翻译。将不良反应信息映射到不良反应本体OAE(the Ontology of Adverse Events),对于OAE中没有的不良反应术语,注释后添加到OAE中,同时将药物信息映射到药物本体NDF-RT(The National Drug File-Reference Terminology)。通过本体构建工具Onto Fox和Ontorat构建心血管药物不良反应中英文本体OCVDAE(The Ontology of Cardiovascular Drug Adverse Events),构建本体时将NDF-RT中的药物成分和作用机制分类集成到OCVDAE中,并建立药物—不良反应之间的联系。基于本体统计分析心血管药物不良反应发生模式,包括药物类别、不良反应类别、常见不良反应等。然后,通过数据挖掘算法(即统计学算法),包括药物类别中不良反应比率(drug proportional class level ratio,PCR),药物类水平比例报告比值比法(the drug class level proportional reporting ratio,C-PRR),药物类水平卡方(the drug class-χ2,C-χ2)、每类药物中包含的药物数量阈值及热图等方法,基于OCVDAE的分类、药物成分和作用机制分类,挖掘有统计意义的不良反应类效应。最后,通过Pub Med中的文献对所发现的部分类效应知识进行验证。结果:共收集了265种心血管药物及相应说明书,提取了1383个中文不良反应术语,对应802个英文不良反应术语,其中391个可在OAE中找到并映射,其余的411个英文术语注释后添加到OAE中,形成了新的OAE术语。共有194种药物映射到了NDF-RT。构建的OCVDAE可在http://www.ontobee.org/ontology/和http://purl.bioontology.org/ontology/OCVDAE网站公开获取。OCVDAE中包括194种药物,736个英文不良反应术语。265种心血管药物涉及9种药物类别,802个英文不良反应术语涉及27种不良反应类别,常见的前10种不良反应包括头痛、恶心、疲乏等。基于PCR的热图分析,发现了多数药物类别对“行为与神经不良反应”和“消化系统不良反应”具有类效应。基于统计方法发现1种药物成分类别“脂类”药物(包括阿托伐他汀、氟伐他汀、非诺贝特)引起8种不良反应(如肌痛、肌病、肌炎等),具有类效应,3种药物作用机制类别(如胆固醇合成抑制剂)引起5种不良反应(如厌食、腹泻等),具有类效应。文献验证了部分知识发现结果。结论:本研究系统性地收集了我国心血管药物及说明书中的心血管药物相关的不良反应。通过复用现有本体OAE和NDF-RT中的术语,以及添加术语及心血管药物—不良反应关系,构建了心血管药物不良反应中英文本体OCVDAE。基于本体分析了心血管药物不良反应的发生模式。并提出使用PCR,C-PRR,C-χ2及药物数量阈值等方法进行药物不良反应类效应的知识发现。
[Abstract]:Objective: to construct the adverse reaction of cardiovascular drugs in China English ontology knowledge base, said the adverse cardiovascular drug system, systematic analysis and knowledge for the cardiovascular response to drug discovery and provide resources, lay the foundation for ontology analysis; cardiovascular adverse drug reaction model based on data mining algorithm; development effect caused by adverse reactions to drugs for knowledge discovery. Methods: according to China's "new materia medica > (SEVENTEENTH EDITION) collection of cardiovascular drugs in use at present in China at the website, collect the cardiovascular drugs manual extraction of drug drug instruction and the adverse reactions and adverse reactions. The information translation information is mapped to the adverse reactions (the Ontology of Adverse OAE body Events in terms of adverse reactions), not in OAE, annotated and added to the OAE, while the drug information is mapped to the drug NDF-RT (The Natio Nal Drug File-Reference Terminology). Onto Fox and Ontorat building construction tools adverse cardiovascular drugs in English ontology OCVDAE (The Ontology of Cardiovascular body by Drug Adverse Events), will build the ontology drug ingredients and mechanism of NDF-RT in the class is integrated into OCVDAE, and set up between adverse drug reactions - contact body statistics. Analysis of the occurrence pattern of cardiovascular adverse reactions based drugs, including drug categories, adverse reaction categories, common adverse reactions. Then, through the data mining algorithm (i.e. statistical algorithm), including adverse drug reaction categories (drug proportional class level ratio ratio, PCR), drug level proportional reporting ratio method (the drug class level proportional reporting ratio, C-PRR), drug level chi square (the drug class- x 2, C- x 2), drugs containing each drug class in number The amount of threshold and thermal methods, OCVDAE based classification, classification and mechanism of drug ingredients, adverse reaction effects have statistical significance mining. Finally, to validate the part class effect of knowledge discovered by Pub Med in the literature. Results: a total of 265 kinds of cardiovascular drugs and the corresponding instructions, from 1383 a Chinese adverse reaction term, corresponding to the 802 English adverse reaction terms, 391 of which can be found in OAE and mapping, notes 411 English remaining after the term is added to the OAE, OAE formed a new term. There are 194 kinds of drugs mapped to NDF-RT. OCVDAE constructed in http://www.ontobee.org/ontology/ and http://purl.bioontology.org/ontology/OCVDAE's public website acquisition includes 194 kinds of drug.OCVDAE, 736 English adverse reaction term.265 cardiovascular drugs involving 9 drug categories, 802 English adverse reaction The term relates to 27 kinds of adverse reaction categories, 10 common adverse reactions include headache, nausea, fatigue and so on. Based on the analysis of the PCR image, found that most drug categories has effect on the adverse reaction behavior and the nervous and digestive system adverse reactions. 1 drug ingredients category "lipid" Drug Statistics based on the method (including atorvastatin, fluvastatin and fenofibrate) caused by 8 kinds of adverse reactions (such as myalgia, myopathy, myositis, etc.) with effect, 3 kinds of mechanism of drug action categories (such as cholesterol synthesis inhibitor) caused by 5 kinds of adverse reactions (such as anorexia, diarrhea, etc.) with literature class effect. To verify the results of knowledge. Conclusion: This study systematically collected adverse cardiovascular drugs and cardiovascular drugs instructions in China related. By reusing the existing ontology OAE and NDF-RT terms, and adding terms The adverse reaction and cardiovascular drugs, establish ontology analysis model based on the cardiovascular response to drug adverse reactions in cardiovascular medicine English ontology OCVDAE.. And put forward the use of PCR, C-PRR, C- x 2 and the amount of drugs threshold for adverse drug reaction effects of knowledge discovery.

【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R972

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