桦木酸纳米粒的制备与表征

发布时间：2018-03-29 06:36

  本文选题：桦木酸　切入点：纳米粒　出处：《中国药房》2017年31期

【摘要】：目的:制备桦木酸纳米粒,并对其进行表征。方法:以乙醇为溶剂、水为反溶剂,采用反溶剂重结晶法制备桦木酸纳米粒。以粒径为指标,采用单因素试验与正交试验优化桦木酸纳米粒处方工艺中桦木酸溶液质量浓度、反溶剂-溶剂体积比、反溶剂滴加速度、反应温度和搅拌速度,并进行验证试验。采用扫描电子显微镜、激光粒度仪、傅里叶红外光谱仪和质谱分析仪对所制得的桦木酸纳米粒进行表征。结果:最优处方工艺为桦木酸溶液质量浓度为3 mg/mL、反溶剂-溶剂体积比为1:1、反溶剂滴加速度为8 mL/min、反应温度为20℃、搅拌速度为900 r/min;所制桦木酸纳米混悬液粒径为(156.0±8.6)nm(n=3),冻干后粒径为(235.0±12.2)nm(n=3),外观近球形、大小均匀、形态较规整;与桦木酸原料药比较,所制桦木酸纳米粒的化学结构没有发生改变,分子量和质荷比无明显变化。结论:成功制得桦木酸纳米粒。
[Abstract]:Objective: to prepare and characterize betulinic acid nanoparticles. Methods: birch acid nanoparticles were prepared by anti-solvent recrystallization with ethanol as solvent and water as antisolvent. Single factor test and orthogonal test were used to optimize the concentration of betulinic acid solution, the volume ratio of antisolvent to solvent, the acceleration of antisolvent drop, the reaction temperature and the stirring speed in the formulation process of birch acid nanoparticles. Using scanning electron microscope, laser particle size meter, Fourier transform infrared spectroscopy (FTIR) and mass spectrometer (MS) were used to characterize the prepared birch acid nanoparticles. Results: the optimum formulation conditions were as follows: the concentration of betulinic acid solution was 3 mg / mL, the volume ratio of antisolvent to solvent was 1: 1, and the acceleration of antisolvent drop was 1: 1. Is 8 mL / min, and the reaction temperature is 20 鈩，

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