单克隆抗体药物致不良反应132例文献分析

发布时间：2018-03-29 15:35

本文选题：单克隆抗体　切入点：药品不良反应　出处：《中国药房》2015年23期

【摘要】：目的:探讨单克隆抗体药物致不良反应(ADR)发生的规律及特点,为临床合理用药提供参考。方法:以"单克隆抗体"或"单抗"为检索词,检索并对中国生物医学文献服务系统、中国知网、万方数据库、维普中文科技期刊数据库1979年1月-2014年12月报道的单克隆抗体药物致ADR的文献34篇、132例并进行分析。结果:132例单克隆抗体药物致ADR中,男性57例(43.18%),女性75例(56.82%),男、女比例为1∶1.3;年龄最小者2岁,最大者111岁;引发ADR的单克隆抗体药物中以阿达木单抗最多,有70例(53.03%);用药在1d内出现ADR的例数最多,为44例(33.33%);单克隆抗体药物致ADR主要为皮肤及其附件损害(20.72%)、全身性反应(18.42%)、心血管系统损害(16.78%)等,具体表现为皮疹、瘙痒、寒战、发热、心慌、心跳加快等。结论:单克隆抗体致ADR较为常见,临床使用时应加强对患者的监护,尤其是儿童和老年患者,以确保患者用药安全,提高临床治疗水平。
[Abstract]:Objective: to investigate the regularity and characteristics of ADRs induced by monoclonal antibodies (McAbs), and to provide a reference for the rational use of drugs in clinic. Methods: using "McAbs" or "McAbs" as the key words, the Chinese biomedical literature service system was searched and analyzed. From January 1979 to December 2014, 34 articles on ADR induced by monoclonal antibody drugs were reported and analyzed. Results among the 132 cases of ADR induced by monoclonal antibody drugs, 132 cases were caused by monoclonal antibody drugs. There were 57 males and 56.82 females, the ratio of males to females was 1: 1.3; the youngest was 2 years old, the oldest was 111 years old; the most monoclonal antibody drugs causing ADR were adamumumab, 70 cases were 53.03g, and the number of ADR was the most in one day. ADR was mainly caused by skin and its adnexa damage (20.72%), systemic reaction (18.42%) and cardiovascular system damage (16.78%), including rash, pruritus, chills, fever, heart attack, etc. Conclusion: ADR caused by monoclonal antibody is more common. We should strengthen the monitoring of patients, especially children and elderly patients, in order to ensure the safety of drug use and improve the clinical treatment level.
【作者单位】：天津市第四中心医院;中国医学科学院生物医学工程研究所/天津市生物医学材料重点实验室;天津中医药大学;
【基金】：国家自然科学基金资助项目(No.81403198) 天津市生物医学材料重点实验室开放课题
【分类号】：R595.3

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