82例吉非替尼不良反应的文献分析

发布时间：2018-03-29 16:22

本文选题：吉非替尼　切入点：药品不良反应　出处：《中国药物警戒》2016年02期

【摘要】：目的分析吉非替尼致药品不良反应(ADR)相关规律和特点,发现吉非替尼使用风险点,为临床合理用药提供参照。方法以"吉非替尼"、"不良反应"、"致"、"gefitinib"等为检索词,检索中国期刊网全文数据库、维普中文期刊全文数据库,按纳入、排除标准共纳入57篇文献,并进行整理和分析。结果共提取82例病例,累及系统-器官主要为胃肠系统损害、皮肤及其附件损害、呼吸系统损害等,不良反应以腹泻、痤疮样皮疹、咳嗽、间质性肺炎等最为常见,严重可致死亡;病例多为男性中老年患者。结论重视吉非替尼在抗癌治疗中的不良反应,加强老年肺癌患者的用药监测,防范严重和罕见的不良反应发生。
[Abstract]:Objective to analyze the related rules and characteristics of adverse drug reactions (ADRs) induced by gefitinib, and to find out the risk points for the use of gifetini, and to provide a reference for the rational use of gifitinib. Methods the key words were "gifitinib", "adverse reaction", "cause", "gefitinib", etc. A total of 57 articles were included in the full text database of China Journal Network and the full text database of Chinese periodicals in China. According to the inclusion and exclusion criteria, 57 articles were collected and analyzed. Results A total of 82 cases were extracted, involving system-organ mainly gastrointestinal system damage. The damage of skin and its appendages, the damage of respiratory system and so on. The most common adverse reactions were diarrhea, acne rash, cough, interstitial pneumonia and so on. Conclusion attention should be paid to the adverse reactions of gefitinib in the treatment of cancer, to strengthen the monitoring of drug use in elderly patients with lung cancer, and to prevent the occurrence of serious and rare adverse reactions.
【作者单位】：辽宁省朝阳市中心医院;
【分类号】：R979.1

【相似文献】