不同吸收促进剂对孟鲁司特钠家兔直肠吸收的促进作用

发布时间：2018-03-30 00:20

本文选题：孟鲁司特钠　切入点：直肠吸收　出处：《第三军医大学学报》2017年09期

【摘要】：目的研究孟鲁司特钠经家兔直肠吸收的程度及不同吸收促进剂对其吸收的影响。方法建立孟鲁司特钠在家兔体内血药浓度的HPLC测定法,测定孟鲁司特钠经家兔直肠给药及在不同吸收促进剂(吐温-80、癸酸钠、胆酸钠、月桂氮卓酮、月桂酸钠、L-精氨酸、EDTA-2Na及盐酸氯丙嗪)作用下的血药浓度,并以静脉给药为对照,对孟鲁司特钠的直肠吸收情况及吸收促进剂作用进行评价。结果孟鲁司特钠本身经直肠吸收极少,所用促进剂对其在肠道的吸收均有影响,并与其使用浓度有关,促进作用为10%吐温-801%癸酸钠0.2%胆酸钠4%月桂氮卓酮3%月桂酸钠1.5%L-精氨酸(P0.05),2%盐酸氯丙嗪与1%EDTA-2Na效果相近,促进作用均较低。结论直肠不是孟鲁司特钠的良好吸收部位,利用吸收促进剂可促进其在直肠的吸收,10%吐温-80促吸收效果最好。
[Abstract]:Objective to study the degree of absorption of montelukast sodium through the rectum of rabbits and the effect of different absorption enhancers on the absorption of montelukast sodium. Methods HPLC method was established for the determination of montelukast sodium in rabbits' blood concentration. The plasma concentrations of montelukast sodium were determined by rectal administration of montelukast through the rectum of rabbits and under the action of different absorption promoters (Tween-80, sodium sebacate, sodium cholate, laurozolone, sodium laurate, L-arginine EDTA-2Na and chlorpromazine hydrochloride), and the intravenous administration of montelukast was used as a control. The rectal absorption of montelukast sodium and the effect of absorption accelerator were evaluated. Results Montelukast sodium itself was rarely absorbed through the rectum, and the use of montelukast sodium had an effect on the absorption of montelukast sodium in the intestine, which was related to the concentration of montelukast sodium. The promoting effect of chlorpromazine hydrochloride was 10% Tween-801% sodium sebacate 0.2% sodium cholate 4% lauroxone 3% sodium laurate 3% sodium laurate 1.5L- arginine P0.05% chlorpromazine hydrochloride and 1TA-2Na. Conclusion rectum is not a good absorption site of montelukast sodium. The effect of 10% Tween-80 on rectal absorption can be promoted by using absorption accelerator.
【作者单位】：第三军医大学西南医院药剂科;
【分类号】：R965

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