使用主成分分析的药品不良反应风险信号挖掘方法探索

发布时间：2018-03-30 09:49

本文选题：头孢呋辛　切入点：心悸　出处：《中国医院药学杂志》2017年01期

【摘要】：目的:探索新的药品不良反应信号的提取、验证方法。方法:对收集到的头孢呋辛不良反应数据,使用Excel数据透视表,按时间统计出不同时间段发生的不良反应例次。通过主成分分析对数据进行降维,根据头孢呋辛各不良反应降维后的主成分得分,在第一、二主成分坐标平面上绘制头孢呋辛不良反应分布图,通过此分布图观察药品不良反应发生与药品使用的相关性,发现新的药品不良反应,并以传统药品不良反应监测方法优势比计算进行验证。结果:头孢呋辛的不良反应分布图中,距离"总计"点较近的分别为"皮疹"、"瘙痒"、"恶心"、"心悸"等,提示头孢呋辛的使用与这些不良反应的出现高度相关。其中,"心悸"未在说明书上载明,是头孢呋辛新的不良反应。头孢呋辛发生"心悸"风险相对其他药品优势比为2.005。结论:主成分分析能够直观鉴别出药品不良反应风险信号。
[Abstract]:Objective: to explore a new method for the extraction and verification of adverse drug reaction signals. Methods: the data collected from cefuroxime were analyzed by using Excel data. According to the time statistics of adverse reactions occurred in different time periods, the data were reduced by principal component analysis. According to the scores of principal components of cefuroxime adverse reactions after dimensionality reduction, in the first place, The distribution map of adverse drug reactions of cefuroxime was drawn on the plane of principal component coordinates. The correlation between adverse drug reactions and drug use was observed by this distribution map, and new adverse drug reactions were found. Results: in the distribution of adverse reactions of cefuroxime, the distance from "total" to "total" was "rash", "pruritus", "nausea", "palpitation" and so on. It is suggested that the use of cefuroxime is highly related to the occurrence of these adverse reactions. Cefuroxime is a new adverse reaction of cefuroxime. The risk of palpitation of cefuroxime is 2.005.Conclusion: principal component analysis can directly identify the risk signal of adverse drug reaction.
【作者单位】：江西省药品不良反应监测中心;
【分类号】：R95

【相似文献】