热水洗涤法降低“铝镁加”原料中钠的含量

发布时间：2018-03-30 23:04

  本文选题：铝镁加　切入点：钠含量　出处：《中国医院药学杂志》2017年08期

【摘要】：目的:为合成符合8.0版《欧洲药典》标准的"铝镁加",采用热水洗涤法降低"铝镁加"原料氢氧化铝和氢氧化镁中的钠含量。方法:采用单因素试验考察洗涤温度、洗涤时间、洗涤次数以及单次水量,采用原子吸收光谱法测定氢氧化铝和氢氧化镁中可溶钠含量。结果:最佳洗涤工艺为,洗涤温度80℃,洗涤时间10 min,洗涤3次,每次10倍量纯化水,可将氢氧化铝与氢氧化镁中钠含量降低至150 ppm以下。结论:该方法可降低"铝镁加"原料氢氧化铝和氢氧化镁中可溶性钠含量,工艺简单,易行,确保"铝镁加"合成后的钠含量符合8.0版《欧洲药典》的质量标准。
[Abstract]:Objective: to synthesize "aluminum-magnesium addition" which meets the standard of "European Pharmacopoeia" 8.0, and to reduce the content of sodium in aluminium hydroxide and magnesium hydroxide by hot water washing method. Methods: single factor test was used to investigate the washing temperature and washing time. The content of soluble sodium in aluminum hydroxide and magnesium hydroxide was determined by atomic absorption spectrometry. Results: the optimum washing conditions were as follows: washing temperature 80 鈩，

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