辅助用药临床应用情况分析

发布时间：2018-04-03 04:31

本文选题：辅助用药　切入点：药物不良反应　出处：《中国医院药学杂志》2017年01期

【摘要】：目的:分析某院2013-2014年临床辅助用药使用情况,了解国内外使用及研究现状,指导临床合理用药。方法:对该院2013-2014年临床辅助用药的用量、不良反应进行统计;评价金额排名第一的药品使用合理性,并通过文献检索了解该药物国内外研究及使用现状。结果:该院2013-2014年辅助治疗药物不良反应报告呈上升趋势;辅助用药金额排名靠前的主要是活血化瘀类、神经营养类药物,中、西药排名第一的药品分别为注射用血栓通及单唾液酸四己糖神经节苷脂,临床不合理使用分别为21例(70%)、6例(20%),其中超适应证用药和用量不适宜为主要问题。查阅国内外相关文献,涉及临床治疗的疾病有几十种,远远超出了药品说明书规定的适应证范围;且Meta分析证据强度不足、可靠性差,不足以支持其超说明书用药情况。结论:医院辅助用药使用的增加,需要进一步加强管理,促进临床合理用药,因病施治。
[Abstract]:Objective: to analyze the use of clinical adjuvant drugs in a hospital from 2013 to 2014, to understand the current situation of clinical use and research at home and abroad, and to guide the rational use of drugs in clinic.Methods: the dosage and adverse reactions of clinical adjuvant drugs in our hospital from 2013 to 2014 were statistically analyzed, the rationality of drug use ranked first in sum of money was evaluated, and the current situation of research and use of this drug at home and abroad was studied through literature retrieval.Results: the ADR report of adjuvant therapy in the year 2013-2014 was on the rise, and the number of adjunctive drugs in the top ranking was mainly promoting blood circulation and removing blood stasis, neurotrophic drugs, middle, middle, and so on.The most important drugs in western medicine were Xueshuantong for injection and tetrahexose ganglioside mono-sialate for injection. The clinical unreasonable use was 21 cases and 6 cases respectively. The main problem was that the overindication and dosage were not suitable.There are dozens of diseases involved in clinical treatment, which are far beyond the indications stipulated in the drug specification, and the Meta analysis is not enough to support its over-description because of its insufficient evidence strength and poor reliability.Conclusion: the increase of hospital adjuvant drug use needs to strengthen the management, promote the rational use of drugs in clinic, and treat the disease.
【作者单位】：扬州市第一人民医院;
【基金】：江苏省自然科学基金资助项目(编号:BK20130432) 江苏省扬州市社会发展科技攻关项目(编号:SGG201230119)
【分类号】：R95

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