我院104例药物性肝损害临床分析

发布时间：2018-04-03 05:04

本文选题：药物性肝损害　切入点：回顾性分析　出处：《中国药房》2015年23期

【摘要】：目的:探讨药物性肝损害(DILI)的临床特点及其发生规律,为临床合理用药提供参考。方法:对我院2005-2014年发生的104例药物性肝损害患者的性别、年龄、发病时间、药品品种、临床表现等临床资料进行回顾性分析。结果:DILI住院病例逐年增多,其中男性47例,女性57例,平均年龄(48.71±13.90)岁;开始用药后至开始出现临床症状时间绝大多数在12周以内;临床症状包括纳差、乏力、身目黄染、上腹不适等,均无特异性;10.57%患者为无症状,临床分型以肝细胞损伤型最多(80.77%),胆汁淤积型次之(12.50%),混合型最少(6.73%)。最常见的引起肝损害药物依次为中药、抗微生物药、抗肿瘤药和神经系统药。结论:DILI患者中女性稍多于男性,好发于40岁以上;临床表现多样且不明显,引起肝损害的药品较多,临床医师在工作中应提高对该病的重视,根据DILI的特征,早期识别,及时停药和合理处置是其诊治的关键。
[Abstract]:Objective: to investigate the clinical characteristics and occurrence of drug-induced liver injury (DILI) and to provide reference for rational drug use.Methods: the clinical data of 104 patients with drug-induced liver injury in our hospital from 2005 to 2014 were analyzed retrospectively, such as sex, age, onset time, drug variety and clinical manifestation.Results there were 47 male and 57 female inpatients, including 47 males and 57 females, with an average age of 48.71 卤13.90 years. The majority of the clinical symptoms were within 12 weeks. The clinical symptoms included anorexia, fatigue, yellow stain of body and eyes.No specific symptoms were found in 10.57% of the patients with upper abdominal discomfort. The most common clinical types were hepatocyte injury type (80.77g), cholestasis type (12.50m) and mixed type (6.73g).The most common drugs causing liver damage are Chinese medicine, anti-microbial drugs, anti-tumor drugs and nervous system drugs.Conclusion there are a little more women than men in the patients with DILI, and they tend to occur over the age of 40. The clinical manifestations are various and not obvious, and there are more drugs that cause liver damage. The clinicians should pay more attention to the disease in their work. According to the characteristics of DILI, they can be identified early.The key of diagnosis and treatment is to stop drugs in time and deal with them reasonably.
【作者单位】：齐齐哈尔市第一医院药学部;
【基金】：齐齐哈尔市科学技术计划项目(No.SFZD-2013067)
【分类号】：R595.3

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