诱导细胞凋亡的海洋抗肿瘤药物研究进展

发布时间：2018-04-03 23:26

本文选题：细胞凋亡　切入点：肿瘤靶向　出处：《药学学报》2016年09期

【摘要】：细胞凋亡又称细胞程序性死亡,在肿瘤的发生、发展过程中具有重要作用。在生物体内可以通过凋亡清除潜在的有害细胞,且不会导致炎症反应或瘢痕形成。因此,诱导细胞凋亡已成为发展化疗药物的重要策略。随着深海采集技术的发展,海洋来源的天然产物已经成为抗肿瘤药物的重要来源。近年来发现了数百种可诱导肿瘤细胞凋亡的海洋来源的化合物,其中大多具有良好的抗肿瘤活性。本文基于不同海洋来源的化合物诱导肿瘤细胞凋亡的分子机制,对其抗肿瘤作用进行了综述,并提出了这类天然产物研究存在的问题及发展前景。
[Abstract]:Apoptosis, also known as programmed cell death, plays an important role in tumorigenesis and development.Apoptosis clears potentially harmful cells in organisms and does not cause inflammation or scar formation.Therefore, inducing apoptosis has become an important strategy for the development of chemotherapeutic drugs.With the development of deep-sea collection technology, natural products from marine sources have become an important source of anti-tumor drugs.In recent years, hundreds of marine compounds which can induce apoptosis of tumor cells have been found, most of which have good antitumor activity.In this paper, based on the molecular mechanism of apoptosis induced by compounds from different marine sources, the antitumor effects of these compounds are reviewed, and the existing problems and development prospects of this kind of natural products are put forward.
【作者单位】：首都医科大学药理系;中国海洋大学医药学院;
【基金】：国家自然科学基金资助项目(8127355,81573457)
【分类号】：R96

【相似文献】