利奈唑胺在脑膜炎患者脑脊液中的药动学及药效学研究

发布时间：2018-04-05 18:03

  本文选题：利奈唑胺　切入点：脑脊液　出处：《中国药房》2015年17期

【摘要】：目的:探讨利奈唑胺在脑膜炎患者脑脊液中的药动学及药效学参数变化。方法:10例重症神经外科患者入组,应用利奈唑胺(600 mg/次,静脉滴注,每日2次,每次静脉滴注60 min)治疗脑室外引流引起的革兰阳性球菌感染所致的脑膜炎,当药物达稳态后测定其在脑脊液中的药动学参数,结合微生物学评价其药效学指标。结果:利奈唑胺在用药2.5 h达到峰浓度(cmax)(5.5±2.5)μg/ml,其谷浓度(cmin)是在用药0和12 h时出现,分别为(3.1±1.3)μg/ml和(3.3±1.8)μg/ml;AUC0-12 h为(105±59)μg·h/ml,性别对AUC0-12 h的影响差异无统计学意义[男性:(112±58)μg·h/ml,女性:(104±49)μg·h/ml,(P0.05)];药物对脑脊液的平均穿透率为67%;最低抑菌浓度(MIC)≤2μg/ml时,AUC0-24 h/MIC的值为112.6,浓度2μg/ml的时间是(11.2±2.8)h,抗菌药物超MIC时间(TMIC)占100%,90%MIC(MIC90)≤4μg/ml时,AUC0-24 h/MIC90的值为57.1,TMIC占54%。结论:利奈唑胺对脑膜炎患者脑脊液有良好的穿透率,常规剂量能达到有效治疗浓度。
[Abstract]:Objective: to investigate the pharmacokinetic and pharmacodynamic parameters of linazolamide in cerebrospinal fluid (CSF) of patients with meningitis.Methods 10 patients with severe neurosurgery were treated with linazolamine 600 mg/, intravenous drip twice a day, each time for 60 minutes, in order to treat meningitis caused by Gram-positive cocci infection caused by ventricular drainage.The pharmacokinetic parameters of the drug in cerebrospinal fluid (CSF) were determined when the drug reached steady state, and its pharmacodynamics was evaluated with microbiology.Results: the peak concentration of linazolamide was 5.5 卤2.5 渭 g / ml at 2.5 h, and its valley concentration was found at 0 h and 12 h after administration.鍒嗗埆涓，

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