我院35例低分子右旋糖酐氨基酸注射液致ADR分析

发布时间：2018-04-10 16:00

本文选题：低分子右旋糖酐氨基酸 + 不良反应　；参考：《中国药房》2017年32期

【摘要】：目的:了解低分子右旋糖酐氨基酸注射液致不良反应(ADR)发生的特点和规律,为临床安全用药提供参考。方法:收集我院2010年1月-2017年1月上报的35例低分子右旋糖酐氨基酸注射液致ADR报告,对患者性别、年龄、ADR报告类型和发生时间、原患疾病及既往药物过敏史、ADR累及器官/系统及临床表现、转归等进行回顾性统计分析。结果:35例低分子右旋糖酐氨基酸注射液致ADR报告中,男性18例(51.43%),女性17例(48.57%);患者年龄最小11岁,最大80岁,平均年龄48.2岁。严重的ADR 4例(11.43%),一般的ADR 31例(88.57%);ADR在用药后10 min~1 h发生率高(71.43%);ADR所涉及的原患疾病以骨折(14例,40.00%)和膝关节炎(8例,22.86%)为主;ADR主要累及消化系统(34.29%)、循环系统(22.86%)和皮肤及其附件(20.00%)等;所有患者在停药及对症处理后均好转或治愈。结论:低分子右旋糖酐氨基酸注射液致ADR的发生率不高,但可致严重的ADR,护理人员可对其加强监护,以减少并发症的发生,避免医患矛盾。
[Abstract]:Objective: to investigate the characteristics and regularity of ADR induced by low molecular dextran amino acid injection, and to provide reference for safe drug use.Methods: 35 cases of ADR caused by low molecular dextran amino acid injection from January 2010 to January 2017 were collected.Retrospective statistical analysis was performed on ADR involving organs / systems, clinical manifestations and outcome of primary diseases and past drug allergies.Results in the report of 35 cases of ADR caused by low molecular weight dextran amino acid injection, there were 18 males (51.43) and 17 females (48.57m) with the youngest age of 11 years, the maximum of 80 years old and the average age of 48.2 years.All patients were cured or improved after drug withdrawal and symptomatic treatment.Conclusion: the incidence of ADR caused by low molecular dextran amino acid injection is not high, but it can cause severe ADR. Nursing staff can strengthen the monitoring to reduce the occurrence of complications and avoid the contradiction between doctors and patients.
【作者单位】：第三军医大学第一附属医院普通外科/微创胃肠外科中心;
【分类号】：R977.4

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