奥卡西平纳米脂质载体的制备及理化性质研究

发布时间：2018-04-11 13:17

本文选题：奥卡西平 + 纳米脂质载体　；参考：《中国药学杂志》2017年07期

【摘要】：目的制备奥卡西平纳米脂质载体(oxcarbazepine nanostructured lipid carriers,OXC-NLC),并对其理化性质进行考察。方法采用乳化溶剂蒸发法制备OXC-NLC,正交试验筛选最优处方,使用扫描电镜、激光粒径测定仪、差示扫描量热仪等考察OXC-NLC的理化性质,通过溶出试验评价其体外释放效果。结果按优化条件制备的OXC-NLC为类球形粒子,平均粒径为(63.04±2.05)nm,粒度分布较均匀,Zeta电位为(-33.52±0.34)mV,DSC结果表明,药物以无定形状态分散于纳米粒中,包封率为(98.16±1.59)%,载药量为(4.27±0.70)%,体外8 h累积释放27.31%。结论采用乳化溶剂蒸发法制备的OXC-NLC粒径大小分布均匀,药物包封率高,具有明显的缓释效果。此制备工艺流程简单、可靠、重现性好。
[Abstract]:Objective to prepare oxcarbazepine nanostructured lipid carriers OXC-NLCL and investigate their physical and chemical properties.Methods OXC-NLC was prepared by emulsifying solvent evaporation method. The optimum prescription was screened by orthogonal test. The physicochemical properties of OXC-NLC were investigated by scanning electron microscope, laser particle size analyzer and differential scanning calorimeter. The release effect in vitro was evaluated by dissolution test.Results the OXC-NLC prepared under the optimized conditions was spherical particles with an average particle size of 63.04 卤2.05 nm, and the average particle size distribution was -33.52 卤0.34 渭 m 路min ~ (-1). The results showed that the drug was dispersed in an amorphous state, the entrapment efficiency was 98.16 卤1.59m, the drug loading was 4.27 卤0.70nm, and the cumulative release was 27.31% at 8 h in vitro.Conclusion the OXC-NLC prepared by emulsified solvent evaporation has uniform particle size distribution, high encapsulation efficiency and obvious slow release effect.The process is simple, reliable and reproducible.
【作者单位】：台州职业技术学院化学制药研究所;
【基金】：浙江省自然科学基金资助项目(LY14E050001) 浙江省教育厅一般科研项目(Y201432771) 台州市科技计划项目(1402ky18,15gy58) 台州职业技术学院博士后科研启动基金项目(2016BSH01)
【分类号】：R943

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