乌司他丁的药理作用机制及临床应用进展

发布时间：2018-04-11 22:22

本文选题：乌司他丁 + 炎症反应　；参考：《中国药房》2017年35期

【摘要】：目的:了解乌司他丁的药理作用及临床应用的研究进展,为临床合理用药提供参考。方法:查阅近年来国内外的相关文献,就乌司他丁的药理作用及临床应用的研究进行归纳和总结。结果与结论:乌司他丁在胰腺炎的治疗中可有效减少胰腺的坏死、水肿,抑制机体炎症反应,对胰腺炎的治疗具有重要价值;在脓毒症的治疗中可减轻患者组织、脏器损伤,抑制脾细胞凋亡,提高脓毒血症患者整体生存率;在休克的治疗中可改善组织、器官的微循环,有助于控制休克状态的持续进展;在缺血-再灌注损伤的治疗中可减少氧自由基的释放及钙内流,调整钙离子的平衡,阻断钙超载导致的兴奋性氨基酸释放及蓄积,通过增加一氧化氮浓度及水解酶活性等机制发挥器官保护作用;在心肺脑复苏的治疗中可降低血清促炎因子水平,达到脑保护作用;在肺损伤的治疗中可通过抑制炎症启动的相关因子起到肺保护作用;在肝脏疾病的治疗中可改善轻/中度患者的相关肝功能指标和凝血功能,缩短住院周期,但对重度患者则无明显治疗作用;在心肺转流等手术患者的治疗中可显著降低肌酸激酶同工酶及心肌肌钙蛋白的水平,对其他组织器官具有一定的保护作用。
[Abstract]:Objective: to investigate the pharmacological effect and clinical application of ulinastatin in order to provide reference for rational use of urinastatin.Methods: the pharmacological effects and clinical application of ulinastatin were summarized and summarized by referring to the relevant literatures at home and abroad in recent years.Results & conclusion: ulinastatin in the treatment of pancreatitis can effectively reduce the necrosis and edema of pancreas, inhibit the inflammatory reaction of the body, and play an important role in the treatment of pancreatitis, and in the treatment of sepsis, it can reduce the injury of tissues and organs of the patients.Inhibiting splenocyte apoptosis and increasing overall survival rate of patients with sepsis can improve the microcirculation of tissues and organs in the treatment of shock and help to control the continuous progress of shock state.The treatment of ischemia-reperfusion injury can reduce the release of oxygen free radicals and calcium influx, adjust the balance of calcium ion, and block the release and accumulation of excitatory amino acids caused by calcium overload.Through increasing the concentration of nitric oxide and the activity of hydrolase, the mechanism of organ protection can reduce the level of serum pro-inflammatory factor in the treatment of cardiopulmonary cerebral resuscitation, and achieve the protective effect of brain.In the treatment of lung injury, the protective effect of lung can be played by inhibiting the factors related to the initiation of inflammation, and in the treatment of liver diseases, it can improve the related liver function index and coagulation function of mild / moderate patients, and shorten the hospitalization period.However, there is no obvious therapeutic effect on severe patients, and the level of creatine kinase isoenzyme and cardiac troponin can be significantly reduced in patients undergoing cardiopulmonary bypass, which has a certain protective effect on other tissues and organs.
【作者单位】：攀枝花学院附属医院麻醉科;广西医科大学研究生院;
【基金】：四川省医学科研青年创新课题计划(No.Q15052)
【分类号】：R96

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